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protein coding gene - gaa1 (SPAC1002.11) - GPI-anchor transamidase complex subunit Gaa1

Gene summary

Standard name
gaa1
Systematic ID
SPAC1002.11
Product
GPI-anchor transamidase complex subunit Gaa1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9US48
ORFeome ID
35/35H11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1816499..1818558 forward strand

Annotation

Disease association

MONDO:0060627 - glycosylphosphatidylinositol biosynthesis defect 15

References:

GO biological process

GO:0016255 - attachment of GPI anchor to protein

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GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0042765 - GPI-anchor transamidase complex

References:

GO:0098553 - lumenal side of endoplasmic reticulum membrane

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GO molecular function

GO:0003923 - GPI-anchor transamidase activity

References:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04114Gaa1Gaa1Pfam
PTHR13304Gaa1PANTHER
PIRSF036762GAA1Gaa1PIRSF
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26563290 - Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling.
Kinoshita T et al. J Lipid Res 2016 Jan;57(1):6-24
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31