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protein coding gene - etd1 (SPAC1006.08) - Spg1-binding protein Etd1

Gene summary

Standard name
etd1
Systematic ID
SPAC1006.08
Product
Spg1-binding protein Etd1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTR4
ORFeome ID
32/32F11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5087979..5089638 forward strand

Annotation

GO biological process

GO:1903473 - positive regulation of mitotic actomyosin contractile ring contraction

References:

GO:1905758 - positive regulation of primary cell septum biogenesis

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GO:0031031 - positive regulation of septation initiation signaling

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GO:1902412 - regulation of mitotic cytokinesis

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GO:0031028 - septation initiation signaling

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GO cellular component

GO:0051285 - cell cortex of cell tip

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GO:0032153 - cell division site

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GO:0051286 - cell tip

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GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0000935 - division septum

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GO:0031097 - medial cortex

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GO molecular function

GO:0005096 - GTPase activator activity

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GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0005055 - binucleate multiseptate cell, septa grouped

References:

Genotypes:

FYPO:0005211 - decreased protein localization to mitotic spindle pole body during anaphase

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0007582 - increased duration of septation initiation network signaling

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Genotypes:

FYPO:0000118 - multiseptate vegetative cell

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0007585 - premature septation initiation network signaling

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Genotypes:

FYPO:0004103 - viable spherical vegetative cell

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0005369 - abolished cell population growth at low temperature

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Genotypes:

FYPO:0001875 - decreased asymmetric protein localization, with protein localized to both mitotic spindle pole bodies

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Genotypes:

FYPO:0002869 - decreased protein localization to cell division site

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Genotypes:

FYPO:0007583 - decreased protein localization to cytoplasm during mitotic telophase

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Genotypes:

FYPO:0005211 - decreased protein localization to mitotic spindle pole body during anaphase

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Genotypes:

FYPO:0007580 - decreased protein localization to mitotic spindle pole body during anaphase B

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0006831 - delayed onset of primary cell septum biogenesis

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Genotypes:

FYPO:0007582 - increased duration of septation initiation network signaling

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

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Genotypes:

FYPO:0002294 - inviable after spore germination with elongated germ tube and cell lysis

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Genotypes:

FYPO:0002816 - inviable after spore germination, without cell division, multinucleate cell with elongated germ tube

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Genotypes:

FYPO:0002024 - inviable elongated multinucleate aseptate vegetative cell

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Genotypes:

FYPO:0001493 - inviable elongated multinucleate vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0005216 - normal protein localization to mitotic spindle pole body during metaphase

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Genotypes:

FYPO:0006832 - premature primary cell septum biogenesis

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF20162Etd1Etd1PFAM
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:19736319 - Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1.
García-Cortés JC et al. J Cell Biol 2009 Sep 07;186(5):739-53
PMID:7845361 - Ethanol-hypersensitive and ethanol-dependent cdc- mutants in Schizosaccharomyces pombe.
Jimenez J et al. Mol Gen Genet 1994 Oct 17;245(1):86-95
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:15933715 - Etd1p is a novel protein that links the SIN cascade with cytokinesis.
Daga RR et al. EMBO J 2005 Jul 06;24(13):2436-46
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29813053 - Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.
G Cortés JC et al. PLoS Genet 2018 May;14(5):e1007388
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:20876564 - Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.
Lahoz A et al. Genetics 2010 Dec;186(4):1261-70
PMID:24336750 - Feedback regulation of SIN by Etd1 and Rho1 in fission yeast.
Alcaide-Gavilán M et al. Genetics 2014 Feb;196(2):455-70
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.
Goyal A et al. Genetics 2012 Apr;190(4):1235-50
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399