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protein coding gene - cca1 (SPAC1093.04c) - CTP 3'-tRNA nucleotidyltransferase Cca1

Gene summary

Standard name
cca1
Systematic ID
SPAC1093.04c
Product
CTP 3'-tRNA nucleotidyltransferase Cca1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTQ0
ORFeome ID
45/45G10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4613715..4618439 reverse strand

Annotation

Disease association

MONDO:0014487 - congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome

References:

MONDO:0014850 - retinitis pigmentosa and erythrocytic microcytosis

References:

GO biological process

GO:1990180 - mitochondrial tRNA 3'-end processing

References:

GO:0001680 - tRNA 3'-terminal CCA addition

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0052927 - CC tRNA cytidylyltransferase activity

References:

GO:0002135 - CTP binding

References:

GO:0000049 - tRNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01149 - sumoylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

PBO:0002606 - multiple translational start sites possible

Protein features

IDNameInterPro nameDB name
PF01743PolyA_polPolA_pol_head_domPFAM
cd05398NT_ClassII-CCAasePolA_pol_head_domCDD
G3DSA:3.30.460.10:FF:000040FUNFAM
SSF81891Poly A polymerase C-terminal region-likeSUPERFAMILY
SSF81301NucleotidyltransferaseNT_sfSUPERFAMILY
G3DSA:3.30.460.10Beta Polymerase, domain 2NT_sfGENE3D
G3DSA:1.10.3090.10GENE3D
PTHR13734TRNA-NUCLEOTIDYLTRANSFERASEPANTHER

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30528393 - Schizosaccharomyces pombe contains separate CC- and A-adding tRNA nucleotidyltransferases.
Reid NE et al. Biochem Biophys Res Commun 2019 Jan 15;508(3):785-790
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.
Zhang K et al. Science 2011 Mar 25;331(6024):1624-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs