protein coding gene - psm3 (SPAC10F6.09c) - mitotic/meiotic cohesin complex ATPase subunit Psm3/Smc3

Gene summary

Standard name

psm3

Systematic ID

SPAC10F6.09c

Product

mitotic/meiotic cohesin complex ATPase subunit Psm3/Smc3

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

smc3

UniProt ID

O42649

ORFeome ID

39/39B08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1220969..1224858 reverse strand

Annotation

Protein features

Orthologs

• SMC3 (HGNC:2468) Homo sapiens
• psm3 (SJAG_05019) Schizosaccharomyces japonicus
• SMC3 (YJL074C) Saccharomyces cerevisiae

References / Literature

PMID:29898918 - Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe .

Sanyal S et al. J Cell Sci 2018 Jul 06;131(13)

PMID:28438891 - A second Wpl1 anti-cohesion pathway requires dephosphorylation of fission yeast kleisin Rad21 by PP4.

Birot A et al. EMBO J 2017 May 15;36(10):1364-1378

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:32755595 - A Structure-Based Mechanism for DNA Entry into the Cohesin Ring.

Higashi TL et al. Mol Cell 2020 Sep 17;79(6):917-933.e9

PMID:21979813 - Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.

Kagami A et al. EMBO Rep 2011 Oct 28;12(11):1189-95

PMID:26687354 - DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism.

Murayama Y et al. Cell 2015 Dec 17;163(7):1628-40

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:29735656 - Suppressor mutation analysis combined with 3D modeling explains cohesin's capacity to hold and release DNA.

Xu X et al. Proc Natl Acad Sci U S A 2018 May 22;115(21):E4833-E4842

PMID:27798241 - An acetyltransferase-independent function of Eso1 regulates centromere cohesion.

Lin SJ et al. Mol Biol Cell 2016 Dec 15;27(25):4002-4010

PMID:24291789 - Biochemical reconstitution of topological DNA binding by the cohesin ring.

Murayama Y et al. Nature 2014 Jan 16;505(7483):367-71

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:28343969 - Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.

Goto Y et al. Curr Biol 2017 Apr 03;27(7):1005-1012

PMID:16682348 - A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4.

Bernard P et al. Curr Biol 2006 May 09;16(9):875-81

PMID:12773391 - Condensin but not cohesin SMC heterodimer induces DNA reannealing through protein-protein assembly.

Sakai A et al. EMBO J 2003 Jun 02;22(11):2764-75

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:38448160 - Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I.

Liu Y et al. Life Sci Alliance 2024 May;7(5)

PMID:21300781 - Psm3 acetylation on conserved lysine residues is dispensable for viability in fission yeast but contributes to Eso1-mediated sister chromatid cohesion by antagonizing Wpl1.

Feytout A et al. Mol Cell Biol 2011 Apr;31(8):1771-86

PMID:26583750 - The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering.

Çamdere G et al. Elife 2015 Nov 19;4

PMID:25993311 - Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.

Phadnis N et al. PLoS Genet 2015 May;11(5):e1005225

PMID:11069892 - Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase.

Tomonaga T et al. Genes Dev 2000 Nov 01;14(21):2757-70

PMID:12750522 - Distinct cohesin complexes organize meiotic chromosome domains.

Kitajima TS et al. Science 2003 May 16;300(5622):1152-5

GO_REF:0000051 - S. pombe keyword mapping

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25619765 - The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.

Folco HD et al. Curr Biol 2015 Feb 02;25(3):348-356

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:33176147 - DNA Binding by the Mis4 Scc2 Loader Promotes Topological DNA Entrapment by the Cohesin Ring.

Kurokawa Y et al. Cell Rep 2020 Nov 10;33(6):108357

PMID:19756689 - SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.

Spirek M et al. Chromosoma 2010 Feb;119(1):59-72

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PB_REF:0000003 - Disease Association Curation

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:31895039 - The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes.

Birot A et al. Elife 2020 Jan 02;9

PMID:34309513 - A Brownian ratchet model for DNA loop extrusion by the cohesin complex.

Higashi TL et al. Elife 2021 Jul 26;10

PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.

Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.

Zemlianski V et al. J Cell Sci 2024 May 23;

PMID:29358048 - Establishment of DNA-DNA Interactions by the Cohesin Ring.

Murayama Y et al. Cell 2018 Jan 25;172(3):465-477.e15

PMID:38830897 - Sororin is an evolutionary conserved antagonist of WAPL.

Prusén Mota I et al. Nat Commun 2024 Jun 03;15(1):4729

GO_REF:0000002 - Comments

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:31278118 - Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.

Folco HD et al. Genetics 2019 Sep;213(1):127-141

PMID:28382430 - DNA Topoisomerase II modulates acetyl-regulation of cohesin-mediated chromosome dynamics.

Lin SJ et al. Curr Genet 2017 Oct;63(5):923-930