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protein coding gene - ctr5 (SPAC1142.05) - plasma membrane copper transporter complex subunit Ctr5

Gene summary

Standard name
ctr5
Systematic ID
SPAC1142.05
Product
plasma membrane copper transporter complex subunit Ctr5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7F9
ORFeome ID
05/05B11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3635409..3636572 forward strand

Annotation

Comment

PBO:0005291 - promoter contains CuSE

Disease association

MONDO:0957211 - neurodegeneration and seizures due to copper transport defect

References:

GO biological process

GO:0015677 - copper ion import

References:

GO:0098705 - copper ion import across plasma membrane

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GO cellular component

GO:0000324 - fungal-type vacuole

References:

GO:0005886 - plasma membrane

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GO molecular function

GO:0005375 - copper ion transmembrane transporter activity

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Modification

MOD:00006 - N-glycosylated residue

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Multi-locus phenotype

FYPO:0003805 - decreased cell population growth on non-fermentable carbon source

References:

Genotypes:

FYPO:0003284 - decreased copper import

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Genotypes:

FYPO:0000726 - sensitive to oxidative stress

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Genotypes:

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003690 - abolished cell population growth on glycerol/ethanol carbon source

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Genotypes:

FYPO:0004039 - abolished primary amine oxidase activity

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Genotypes:

FYPO:0002128 - abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth

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Genotypes:

FYPO:0003284 - decreased copper import

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0006212 - inviable after spore germination, before germ tube formation, during copper ion starvation

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Genotypes:

FYPO:0009036 - resistance to benzamidine

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0001987 - sensitive to high pH

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Genotypes:

FYPO:0000111 - sensitive to rapamycin

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Subunit composition

PBO:0015221 - heteromeric(2)

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF04145CtrCop_transporterPFAM
PTHR12483SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERSCop_transporterPANTHER

Orthologs

References / Literature

PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.
Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72
PMID:25651869 - Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.
Doi A et al. Genes Cells 2015 Apr;20(4):292-309
PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.
Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697
PMID:20694150 - Copper-dependent trafficking of the Ctr4-Ctr5 copper transporting complex.
Ioannoni R et al. PLoS One 2010 Aug 04;5(8):e11964
PMID:24569997 - Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.
Plante S et al. J Biol Chem 2014 Apr 04;289(14):10168-81
PMID:17477863 - Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
Rustici G et al. Genome Biol 2007;8(5):R73
PMID:28191457 - The copper transport-associated protein Ctr4 can form prion-like epigenetic determinants in Schizosaccharomyces pombe .
Sideri T et al. Microb Cell 2017 Jan;4(1):16-28
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:21832151 - Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.
Kashiwazaki J et al. Mol Biol Cell 2011 Oct;22(19):3658-70
PMID:25733668 - Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe.
Mourer T et al. J Biol Chem 2015 Apr 17;290(16):10176-90
PMID:28572514 - Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination.
Plante S et al. J Biol Chem 2017 Jul 14;292(28):11896-11914
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:18723604 - Copper distributed by Atx1 is available to copper amine oxidase 1 in Schizosaccharomyces pombe.
Peter C et al. Eukaryot Cell 2008 Oct;7(10):1781-94
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:11274192 - Identification of a novel high affinity copper transport complex in the fission yeast Schizosaccharomyces pombe.
Zhou H et al. J Biol Chem 2001 Jun 08;276(23):20529-35
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16385131 - Functional dissection of Ctr4 and Ctr5 amino-terminal regions reveals motifs with redundant roles in copper transport.
Beaudoin J et al. Microbiology (Reading) 2006 Jan;152(Pt 1):209-222
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:28882432 - Analysis of ambient pH stress response mediated by iron and copper intake in Schizosaccharomyces pombe.
Higuchi Y et al. J Biosci Bioeng 2018 Jan;125(1):92-96
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12