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protein coding gene - SPAC11D3.11c - DNA-binding transcription factor, zn(2)-C6 fungal-type, truncated

Gene summary

Systematic ID
SPAC11D3.11c
Product
DNA-binding transcription factor, zn(2)-C6 fungal-type, truncated
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC11D3.12c
UniProt ID
G2TRN9
ORFeome ID
27/27E08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 126951..129294 reverse strand

Annotation

GO biological process

GO:0000122 - negative regulation of transcription by RNA polymerase II

References:

GO molecular function

GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

References:

GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

References:

GO:0008270 - zinc ion binding

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

Warnings

PBO:0000070 - gene structure updated

References:

PBO:0000082 - new gene

References:

PBO:0000145 - previously annotated as pseudogene

References:

PBO:0091240 - truncation LoF variant reverts to normal in strain CBS5557

References:

Protein features

IDNameInterPro nameDB name
PF00172Zn_clusZn2Cys6_DnaBDPFAM
PF04082Fungal_transXnlR_reg_domPFAM
cd12148fungal_TF_MHRCDD
cd00067GAL4Zn2Cys6_DnaBDCDD
PS00463ZN2_CY6_FUNGAL_1Zn2Cys6_DnaBDPROSITE_PATTERNS
PS50048ZN2_CY6_FUNGAL_2Zn2Cys6_DnaBDPROSITE_PROFILES
SM00066gal4_2Zn2Cys6_DnaBDSMART
SM00906Fungal_trans_2XnlR_reg_domSMART
G3DSA:4.10.240.10:FF:000018FUNFAM
SSF57701Zn2/Cys6 DNA-binding domainZn2-C6_fun-type_DNA-bd_sfSUPERFAMILY
G3DSA:4.10.240.10Zn2-C6_fun-type_DNA-bd_sfGENE3D
PTHR31313TY1 ENHANCER ACTIVATORTranscr_Regulatory_ElemPANTHER

References / Literature

GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115
PMID:26615217 - Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.
Hu W et al. Genome Biol Evol 2015 Nov 27;7(12):3496-510
GO_REF:0000002 - Comments
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12