protein coding gene - ync13 (SPAC11E3.02c) - Munc family exocytic/endocytic regulator Ync13

Gene summary

Standard name

ync13

Systematic ID

SPAC11E3.02c

Product

Munc family exocytic/endocytic regulator Ync13

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O13683

ORFeome ID

39/39C07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 5281778..5285828 reverse strand

Annotation

Protein features

Orthologs

• UNC13B (HGNC:12566) Homo sapiens
• UNC13D (HGNC:23147) Homo sapiens
• UNC13C (HGNC:23149) Homo sapiens
• UNC13A (HGNC:23150) Homo sapiens
• BAIAP3 (HGNC:948) Homo sapiens
• ync13 (SJAG_02572) Schizosaccharomyces japonicus
• YOR296W Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.

Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7

PMID:41144523 - The Ync13-Rga7-Rng10 complex selectively coordinates secretory vesicle trafficking and secondary septum formation during cytokinesis.

Zhang S et al. PLoS Biol 2025 Oct 27;23(10):e3003466

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:16489217 - Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.

Kao RS et al. Genetics 2006 May;173(1):49-61

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:34910579 - Involvement of Smi1 in cell wall integrity and glucan synthase Bgs4 localization during fission yeast cytokinesis.

Longo LVG et al. Mol Biol Cell 2022 Feb 01;33(2):ar17

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

InterPro:IPR019558 - Unknown title

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.

Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279

PMID:40629316 - Ca 2+ -dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion.

Mu B et al. BMC Biol 2025 Jul 09;23(1):207

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101