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protein coding gene - ync13 (SPAC11E3.02c) - Munc family exocytic/endocytic regulator Ync13

Gene summary

Standard name
ync13
Systematic ID
SPAC11E3.02c
Product
Munc family exocytic/endocytic regulator Ync13
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13683
ORFeome ID
39/39C07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5281778..5285828 reverse strand

Annotation

Disease association

MONDO:0012146 - familial hemophagocytic lymphohistiocytosis 3

References:

MONDO:0980942 - intellectual developmental disorder with seizures and dysmorphic facies

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MONDO:0980940 - neurodevelopmental disorder with hypotonia, epilepsy, and absent speech

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MONDO:0980941 - neurodevelopmental disorder with speech delay, movement abnormalities, and seizures

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GO biological process

GO:0120207 - endocytosis, site selection

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GO:0006887 - exocytosis

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GO cellular component

GO:0051285 - cell cortex of cell tip

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GO:0032153 - cell division site

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GO:0051286 - cell tip

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GO:0090689 - cleavage furrow leading edge

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GO:0005829 - cytosol

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GO molecular function

GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding

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GO:0001786 - phosphatidylserine binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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Multi-locus phenotype

FYPO:0003440 - cell lysis during cytokinesis

References:

Genotypes:

FYPO:0006883 - decreased exocytosis at cell division site

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Genotypes:

FYPO:0004653 - delayed onset of actomyosin contractile ring contraction

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001581 - vacuolated

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein features

PBO:0111864 - C2 domain

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003440 - cell lysis during cytokinesis

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Genotypes:

FYPO:0003203 - curved septum

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0004651 - decreased secondary cell septum thickness

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0003213 - explosive cytokinetic cell separation resulting in vegetative cell lysis

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Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

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Genotypes:

FYPO:0004655 - increased protein localization to cell division site

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Genotypes:

FYPO:0006880 - increased protein localization to center of cell division site

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Genotypes:

FYPO:0002410 - inviable vacuolated vegetative cell, abnormal cell shape, normal cell size

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003212 - kinked septum

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Genotypes:

FYPO:0001865 - normal negative regulation of transcription by glucose

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Genotypes:

FYPO:0008456 - normal plasma membrane hypoosmotic expansion during vegetative growth

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Genotypes:

FYPO:0002442 - normal protein localization to cell division site

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Genotypes:

FYPO:0004478 - protein mislocalized to mitochondrion

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00168C2C2_domPfam
PF06292MUNMUN_domPfam
PF27826Git1_TPR-like_3rdGit1-like_TPR-like_3rdPfam
cd04043C2_Munc13_fungalCDD
PS50004C2C2_domPROSITE profiles
PS51258MHD1Munc13_1PROSITE profiles
PS51259MHD2Munc13_dom-2PROSITE profiles
G3DSA:1.10.357.50CATH-Gene3D
G3DSA:1.20.58.1100CATH-Gene3D
G3DSA:2.60.40.150C2_domain_sfCATH-Gene3D
SSF49562C2_domain_sfSUPERFAMILY
PTHR47263PANTHER

Orthologs

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:40629316 - Ca 2+ -dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion.
Mu B et al. BMC Biol 2025 Jul 09;23(1):207
PMID:16489217 - Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.
Kao RS et al. Genetics 2006 May;173(1):49-61
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:34910579 - Involvement of Smi1 in cell wall integrity and glucan synthase Bgs4 localization during fission yeast cytokinesis.
Longo LVG et al. Mol Biol Cell 2022 Feb 01;33(2):ar17
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:41144523 - The Ync13-Rga7-Rng10 complex selectively coordinates secretory vesicle trafficking and secondary septum formation during cytokinesis.
Zhang S et al. PLoS Biol 2025 Oct 27;23(10):e3003466
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
InterPro:IPR019558 - Unknown title
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.
Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279