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protein coding gene - pyp3 (SPAC11E3.09) - protein tyrosine phosphatase Pyp3

Gene summary

Standard name
pyp3
Systematic ID
SPAC11E3.09
Product
protein tyrosine phosphatase Pyp3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P32587
ORFeome ID
52/52A10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5298715..5300189 forward strand

Annotation

Disease association

MONDO:0005148 - type 2 diabetes mellitus

References:

GO biological process

GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle

References:

GO:0007165 - signal transduction

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0004725 - protein tyrosine phosphatase activity

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Multi-locus phenotype

FYPO:0001933 - abnormal mitotic cell cycle regulation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0000502 - abnormally arrested mitotic cell cycle progression

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Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0004191 - increased RNA level during cellular response to hydroxyurea

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Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0004603 - inviable after spore germination, without cell division, elongated cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0001046 - premature mitosis

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Genotypes:

FYPO:0006935 - viable cell with normal cell morphology during nitrogen starvation

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Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0004099 - normal mitotic chromosome condensation

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Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0009084 - sensitive to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00102Y_phosphatasePTP_catPfam
cd18533PTP_fungalCDD
PS00383TYR_PHOSPHATASE_1Tyr_Pase_ASPROSITE patterns
PS50055TYR_PHOSPHATASE_PTPPTP_catPROSITE profiles
PS50056TYR_PHOSPHATASE_2Tyr_Pase_domPROSITE profiles
SM00194PTPcPTP_catSMART
SM00404PTPc_motifTyr_Pase_catSMART
PR00700PRTYPHPHTASEPTP_catPRINTS
G3DSA:3.90.190.10:FF:000115CATH-FunFam
G3DSA:3.90.190.10Prot-tyrosine_phosphatase-likeCATH-Gene3D
SSF52799Prot-tyrosine_phosphatase-likeSUPERFAMILY
PTHR19134Protein-Tyr_PhosphatasePANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:15629716 - Inactivation of the Cdc25 phosphatase by the stress-activated Srk1 kinase in fission yeast.
López-Avilés S et al. Mol Cell 2005 Jan 07;17(1):49-59
PMID:12399381 - The sal3(+) gene encodes an importin-beta implicated in the nuclear import of Cdc25 in Schizosaccharomyces pombe.
Chua G et al. Genetics 2002 Oct;162(2):689-703
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29735745 - Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1.
Schiklenk C et al. J Cell Biol 2018 Jul 02;217(7):2383-2401
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:7961734 - Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man.
Mondesert O et al. J Biol Chem 1994 Nov 11;269(45):27996-9
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:1464318 - Pyp3 PTPase acts as a mitotic inducer in fission yeast.
Millar JB et al. EMBO J 1992 Dec;11(13):4933-41
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:19750219 - The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.
Dutta C et al. PLoS One 2009 Sep 11;4(9):e6944
PMID:36095128 - Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2.
Anil AT et al. Nucleic Acids Res 2022 Sep 23;50(17):10000-10014
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:1464319 - Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast.
Millar JB et al. EMBO J 1992 Dec;11(13):4943-52
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:11238887 - Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints.
Rhind N et al. Mol Cell Biol 2001 Mar;21(5):1499-508
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
PMID:15548596 - Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.
Webb CJ et al. Mol Biol Cell 2005 Feb;16(2):584-96