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protein coding gene - SPAC11E3.12 - mitochondrial thioredoxin family protein, implicated in sulfur cluster assembly

Gene summary

Systematic ID
SPAC11E3.12
Product
mitochondrial thioredoxin family protein, implicated in sulfur cluster assembly
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13691
ORFeome ID
52/52A01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 5305724..5308686 forward strand

Annotation

Disease association

MONDO:0032612 - mitochondrial complex I deficiency, nuclear type 7

References:

GO biological process

GO:0017004 - cytochrome complex assembly

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GO cellular component

GO:0005739 - mitochondrion

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GO molecular function

GO:0016491 - oxidoreductase activity

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009008 - increased vegetative cell population viability

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0004162 - loss of viability upon glucose starvation

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Genotypes:

FYPO:0007035 - normal growth on 5-fluorouracil

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000099 - sensitive to canavanine

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0034749 - Unlike the human ortholog, this protein is not associated with the NADH complex. Fission yeast does not have the other 40 subunits that are present in that complex in mammals. See associated reference for more information on the human protein

References:

Protein features

IDNameInterPro nameDB name
PF012572Fe-2S_thioredxPFAM
cd03064TRX_Fd_NuoENuoE_domCDD
PS01099COMPLEX1_24KNuoE-likePROSITE_PATTERNS
SSF52833Thioredoxin-likeThioredoxin-like_sfSUPERFAMILY
G3DSA:1.10.10.1590NuoE_NGENE3D
G3DSA:3.40.30.10GlutaredoxinGENE3D
PTHR10371NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIALPANTHER
PIRSF000216NDH-1_ENuoE-likePIRSF

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:1518044 - Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.
Walker JE et al. J Mol Biol 1992 Aug 20;226(4):1051-72
PMID:25669599 - Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.
Nguyen TT et al. Sci Rep 2015 Feb 11;5:8400
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.
Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)
PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.
Rodriguez-Lopez M et al. Elife 2022 Jan 05;11