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protein coding gene - idh1 (SPAC11G7.03) - isocitrate dehydrogenase (NAD+) subunit 1 Idh1

Gene summary

Standard name
idh1
Systematic ID
SPAC11G7.03
Product
isocitrate dehydrogenase (NAD+) subunit 1 Idh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
glu3
UniProt ID
O13696
ORFeome ID
16/16E04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3966766..3968132 forward strand

Annotation

Disease association

MONDO:0012943 - retinitis pigmentosa 46

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GO biological process

GO:0006099 - tricarboxylic acid cycle

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005759 - mitochondrial matrix

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GO molecular function

GO:0004449 - isocitrate dehydrogenase (NAD+) activity

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GO:0000287 - magnesium ion binding

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Modification

MOD:00046 - O-phospho-L-serine

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0008022 - abolished cell population growth on alanine nitrogen source

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Genotypes:

FYPO:0008023 - abolished cell population growth on leucine nitrogen source

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Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0000249 - decreased cell population growth on ammonia nitrogen source

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Genotypes:

FYPO:0009078 - decreased cell population growth on ethanol carbon source

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

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Genotypes:

FYPO:0000035 - growth auxotrophic for arginine

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Genotypes:

FYPO:0005877 - growth auxotrophic for glutamate

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Genotypes:

FYPO:0009028 - increased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0008018 - normal growth on glutamine nitrogen source

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Genotypes:

FYPO:0009032 - resistance to bortezomib

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0001188 - sensitive to Calcofluor White

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00180Iso_dhIsoPropMal-DH-like_domPFAM
PS00470IDH_IMDHIsoCit/isopropylmalate_DH_CSPROSITE_PATTERNS
SM01329Iso_dh_2IsoPropMal-DH-like_domSMART
G3DSA:3.40.718.10:FF:000001FUNFAM
SSF53659Isocitrate/Isopropylmalate dehydrogenase-likeSUPERFAMILY
G3DSA:3.40.718.10Isopropylmalate DehydrogenaseGENE3D
PTHR11835DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATEPANTHER
TIGR00175mito_nad_idhIsocitrate_DH_NADNCBIFAM

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:32896087 - Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast.
Malecki M et al. EMBO Rep 2020 Nov 05;21(11):e50845
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37164017 - Optimization of energy production and central carbon metabolism in a non-respiring eukaryote.
Alam S et al. Curr Biol 2023 Jun 05;33(11):2175-2186.e5
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23213482 - TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast.
Du W et al. Biol Open 2012 Sep 15;1(9):884-8
PMID:10975257 - Isolation and RNA-binding analysis of NAD+ -isocitrate dehydrogenases from Kluyveromyces lactis and Schizosaccharomyces pombe.
Elzinga SD et al. Curr Genet 2000 Aug;38(2):87-94
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:7903653 - Enzyme defects in glutamate-requiring strains of Schizosaccharomyces pombe.
Barel I et al. FEMS Microbiol Lett 1993 Nov 01;113(3):267-72
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12