protein coding gene - mam2 (SPAC11H11.04) - pheromone p-factor receptor Mam2

Gene summary

Standard name

mam2

Systematic ID

SPAC11H11.04

Product

pheromone p-factor receptor Mam2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q00619

ORFeome ID

15/15H10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4780688..4781922 forward strand

Annotation

Protein features

Orthologs

• mam2 (SJAG_01978) Schizosaccharomyces japonicus
• STE2 (YFL026W) Saccharomyces cerevisiae

References / Literature

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:15659165 - A constitutively active GPCR retains its G protein specificity and the ability to form dimers.

Ladds G et al. Mol Microbiol 2005 Jan;55(2):482-97

PMID:27020743 - Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating.

Merlini L et al. Curr Biol 2016 Apr 25;26(8):1117-25

PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.

Schwer B et al. mBio 2024 Jun 20;:e0125224

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:4716873 - Genes involved in mating type expression of fission yeast.

Egel R Mol Gen Genet 1973 May 28;122(4):339-43

PMID:11554925 - The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating.

Pereira PS et al. Genes Cells 2001 Sep;6(9):789-802

PMID:23900842 - A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.

Croft W et al. J Biol Chem 2013 Sep 20;288(38):27327-27342

PMID:8668157 - Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression.

Yabana N et al. Mol Cell Biol 1996 Jul;16(7):3420-8

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000002 - Comments

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:12723602 - Characterization of the Prr1 response regulator with special reference to sexual development in Schizosaccharomyces pombe.

Nakamichi N et al. Biosci Biotechnol Biochem 2003 Mar;67(3):547-55

PMID:22500108 - Interaction between pheromone and its receptor of the fission yeast Schizosaccharomyces pombe examined by a force spectroscopy study.

Sasuga S et al. J Biomed Biotechnol 2012;2012:804793

PMID:9606213 - FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation.

Petersen J et al. J Cell Biol 1998 Jun 01;141(5):1217-28

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:25252312 - [Ash2, a subunit of histone H3K4 methyltransferase complex, is involved in the sporulation in Schizosaccharomyces pombe].

Wang W et al. Yi Chuan 2014 Sep;36(9):943-51

PMID:11461899 - Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2.

Chung KS et al. J Biol Chem 2001 Oct 26;276(43):40190-201

PMID:27798845 - Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion.

Dudin O et al. Genes Dev 2016 Oct 01;30(19):2226-2239

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:39094565 - Mapping the dynamics of epigenetic adaptation in S. pombe during heterochromatin misregulation.

Larkin A et al. Dev Cell 2024 Jul 26;

PMID:15580593 - Development of a semi-quantitative plate-based alpha-galactosidase gene reporter for Schizosaccharomyces pombe and its use to isolate a constitutively active Mam2.

Goddard A et al. Yeast 2005 Jan 15;22(1):31-41

PMID:24147005 - The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis.

Weston C et al. PLoS One 2013;8(10):e77487

PMID:25157670 - One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs.

Lock A et al. Biochim Biophys Acta 2014 Dec;1838(12):3036-51

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:7923372 - Cooperative interaction of S. pombe proteins required for mating and morphogenesis.

Chang EC et al. Cell 1994 Oct 07;79(1):131-41

PMID:8807800 - Autocrine response of Schizosaccharomyces pombe haploid cells to mating pheromones.

Kitamura K et al. FEMS Microbiol Lett 1996 Sep 15;143(1):41-5

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:1657593 - The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein.

Kitamura K et al. EMBO J 1991 Dec;10(12):3743-51

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.

Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82

PMID:24167631 - Klf1, a C2H2 zinc finger-transcription factor, is required for cell wall maintenance during long-term quiescence in differentiated G0 phase.

Shimanuki M et al. PLoS One 2013;8(10):e78545

PMID:8264618 - Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.

Xu HP et al. Mol Cell Biol 1994 Jan;14(1):50-8

PMID:8534915 - Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway.

Kanoh J et al. Mol Biol Cell 1995 Sep;6(9):1185-95

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963