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protein coding gene - atl1 (SPAC1250.04c) - alkyltransferase-like protein Atl1

Gene summary

Standard name
atl1
Systematic ID
SPAC1250.04c
Product
alkyltransferase-like protein Atl1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTN9
ORFeome ID
01/01G07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5096895..5097662 forward strand

Annotation

GO biological process

GO:0070911 - global genome nucleotide-excision repair

References:

GO:0006283 - transcription-coupled nucleotide-excision repair

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0003684 - damaged DNA binding

References:

GO:0032132 - O6-alkylguanine-DNA binding

References:

GO:0003908 - methylated-DNA-[protein]-cysteine S-methyltransferase activity

References:

Multi-locus phenotype

FYPO:0007149 - normal growth on N-methyl-N'-nitro-N-nitrosoguanidine

References:

Genotypes:

FYPO:0001813 - sensitive to N-methyl-N'-nitro-N-nitrosoguanidine

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0000658 - decreased DNA binding

References:

Genotypes:

FYPO:0004371 - decreased duration of S-phase DNA damage checkpoint

References:

Genotypes:

FYPO:0006012 - elongated cell with abolished shmoo formation

References:

Genotypes:

FYPO:0001813 - sensitive to N-methyl-N'-nitro-N-nitrosoguanidine

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01035DNA_binding_1MethylDNA_cys_MeTrfase_DNA-bdPFAM
cd06445ATaseMethylDNA_cys_MeTrfase_DNA-bdCDD
SSF46767Methylated DNA-protein cysteine methyltransferase, C-terminal domainMethylDNA_cys_MeTrfase_DNAbSUPERFAMILY
G3DSA:1.10.10.10WH-like_DNA-bd_sfGENE3D
PTHR429426-O-METHYLGUANINE DNA METHYLTRANSFERASEATL_DNA_repairPANTHER
TIGR00589ogtMethylDNA_cys_MeTrfase_DNA-bdNCBIFAM

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16679453 - A novel DNA damage recognition protein in Schizosaccharomyces pombe.
Pearson SJ et al. Nucleic Acids Res 2006;34(8):2347-54
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23112169 - Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.
Wilkinson OJ et al. Proc Natl Acad Sci U S A 2012 Nov 13;109(46):18755-60
PMID:27538348 - Set3 contributes to heterochromatin integrity by promoting transcription of subunits of Clr4-Rik1-Cul4 histone methyltransferase complex in fission yeast.
Yu Y et al. Sci Rep 2016 Aug 19;6:31752
PMID:19516334 - Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Tubbs JL et al. Nature 2009 Jun 11;459(7248):808-13
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39330577 - Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O 6 -Alkylated Guanine Bases in DNA.
Yaakub H et al. Toxics 2024 Sep 04;12(9)
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:22658721 - Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Latypov VF et al. Mol Cell 2012 Jul 13;47(1):50-60
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.
Malecki M et al. Genome Biol 2016 Nov 25;17(1):240