protein coding gene - sxa2 (SPAC1296.03c) - serine carboxypeptidase Sxa2
Gene summary
- Standard name
- sxa2
- Systematic ID
- SPAC1296.03c
- Product
- serine carboxypeptidase Sxa2
- Organism
- Schizosaccharomyces pombe
(fission yeast)
- UniProt ID
- P32825
- ORFeome ID
- 24/24G01
- Characterisation status
- biological role published
- Feature type
- mRNA gene
- Genomic location
- chromosome I: 712217..714449 reverse strand
Annotation
Qualitative gene expression
Quantitative gene expression
Protein features
| ID | Name | InterPro name | DB name |
| PF00450 | Peptidase_S10 | Peptidase_S10 | Pfam |
| PS00131 | CARBOXYPEPT_SER_SER | Ser_caboxypep_ser_AS | PROSITE patterns |
| PS00560 | CARBOXYPEPT_SER_HIS | Ser_caboxypep_his_AS | PROSITE patterns |
| PR00724 | CRBOXYPTASEC | Peptidase_S10 | PRINTS |
| G3DSA:3.40.50.1820 | | AB_hydrolase_fold | CATH-Gene3D |
| SSF53474 | | AB_hydrolase_fold | SUPERFAMILY |
| PTHR11802 | | Peptidase_S10 | PANTHER |
| Signal Peptide | | | DeepTMHMM-Signal-Peptide |
| mobidb-lite-Disorder | disorder_prediction | | MobiDB-Disorder |
Orthologs
- sxa2 (SJAG_00975) Schizosaccharomyces japonicus
References / Literature
- PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
- Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
- PMID:10792724 - Sxa2 is a serine carboxypeptidase that degrades extracellular P-factor in the fission yeast Schizosaccharomyces pombe.
- Ladds G et al. Mol Microbiol 2000 Apr;36(2):377-90
- PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
- Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
- PMID:25803873 - Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe.
- Núñez A et al. PLoS One 2015;10(3):e0121059
- PMID:30279276 - Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction.
- Gallo Castro D et al. J Cell Biol 2018 Dec 03;217(12):4215-4229
- PMID:31239353 - Zinc-dependent activation of the Pho8 alkaline phosphatase in Schizosaccharomyces pombe .
- Hu YM et al. J Biol Chem 2019 Aug 16;294(33):12392-12404
- PMID:24147005 - The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis.
- Weston C et al. PLoS One 2013;8(10):e77487
- PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
- Hayles J et al. Open Biol 2013 May 22;3(5):130053
- PMID:11950884 - Different mechanisms of cell polarisation in vegetative and shmooing growth in fission yeast.
- Niccoli T et al. J Cell Sci 2002 Apr 15;115(Pt 8):1651-62
- PMID:7499258 - Cloning and functional analysis of the ndk1 gene encoding nucleoside-diphosphate kinase in Schizosaccharomyces pombe.
- Izumiya H et al. J Biol Chem 1995 Nov 17;270(46):27859-64
- PMID:8879048 - Purification of Sxa2, a carboxypeptidase involved in pheromone recovery in fission yeast.
- Ladds G et al. Biochem Soc Trans 1996 Aug;24(3):504S
- PMID:19669754 - Enhanced protein secretion from multiprotease-deficient fission yeast by modification of its vacuolar protein sorting pathway.
- Idiris A et al. Appl Microbiol Biotechnol 2010 Jan;85(3):667-77
- PMID:9191273 - The role of Sxa1 in pheromone recovery in Schizosaccharomyces pombe.
- Hughes M et al. Biochem Soc Trans 1997 May;25(2):229S
- PMID:8668157 - Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression.
- Yabana N et al. Mol Cell Biol 1996 Jul;16(7):3420-8
- PMID:11554925 - The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating.
- Pereira PS et al. Genes Cells 2001 Sep;6(9):789-802
- PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
- Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
- PMID:8736868 - Characterisation of Sxa2, a carboxypeptidase involved in pheromone recovery in fission yeast.
- Ladds G et al. Biochem Soc Trans 1996 May;24(2):210S
- PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.
- Tsukahara K et al. Mol Cell Biol 1998 Aug;18(8):4488-98
- PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
- UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
- PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
- Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
- PMID:9191272 - Sxa2, a carboxypeptidase that degrades extracellular pheromone in fission yeast.
- Ladds G et al. Biochem Soc Trans 1997 May;25(2):228S
- PMID:1549128 - Schizosaccharomyces pombe sxa1+ and sxa2+ encode putative proteases involved in the mating response.
- Imai Y et al. Mol Cell Biol 1992 Apr;12(4):1827-34
- PMID:27022830 - Microscopy of Fission Yeast Sexual Lifecycle.
- Vjestica A et al. J Vis Exp 2016 Mar 09;(109)
- PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
- Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
- PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
- Mata J et al. Nat Genet 2002 Sep;32(1):143-7
- PMID:21153812 - Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe.
- Mukaiyama H et al. Appl Microbiol Biotechnol 2011 Apr;90(1):203-13
- PMID:16802154 - Enhanced productivity of protease-sensitive heterologous proteins by disruption of multiple protease genes in the fission yeast Schizosaccharomyces pombe.
- Idiris A et al. Appl Microbiol Biotechnol 2006 Nov;73(2):404-20
- PMID:21511999 - Comparative functional genomics of the fission yeasts.
- Rhind N et al. Science 2011 May 20;332(6032):930-6
- PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.
- Idiris A et al. Yeast 2006 Jan 30;23(2):83-99
- PMID:8314086 - The fission yeast mating pheromone P-factor: its molecular structure, gene structure, and ability to induce gene expression and G1 arrest in the mating partner.
- Imai Y et al. Genes Dev 1994 Feb 01;8(3):328-38
- PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
- Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
- PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
- Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
- PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
- Rodríguez-López M et al. Elife 2023 Oct 03;12
- PMID:7900424 - Assessment of pheromone production and response in fission yeast by a halo test of induced sporulation.
- Egel R et al. Yeast 1994 Oct;10(10):1347-54
- PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
- Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
- PMID:8654750 - Characterisation of Sxa2, a protease involved in pheromone communication in fission yeast.
- Ladds G et al. Biochem Soc Trans 1995 Nov;23(4):565S
- PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
- Blyth J et al. Genetics 2018 Feb;208(2):589-603
- PMID:9599405 - Extracellular degradation of agonists as an adaptive mechanism.
- Ladds G et al. Semin Cell Dev Biol 1998 Apr;9(2):111-8
- PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
- Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
- PMID:27020743 - Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating.
- Merlini L et al. Curr Biol 2016 Apr 25;26(8):1117-25
- PMID:8861202 - The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe.
- Ladds G et al. Mol Microbiol 1996 Apr;20(1):35-42
