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protein coding gene - icp55 (SPAC12B10.05) - mitochondrial intermediate cleavage peptidase Icp55

Gene summary

Standard name
icp55
Systematic ID
SPAC12B10.05
Product
mitochondrial intermediate cleavage peptidase Icp55
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ppp43
UniProt ID
Q10439
ORFeome ID
37/37B03
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 4582370..4584511 forward strand

Annotation

Disease association

MONDO:0013163 - nephronophthisis-like nephropathy 1

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GO biological process

GO:0034982 - mitochondrial protein processing

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GO cellular component

GO:0099617 - matrix side of mitochondrial inner membrane

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GO:0005739 - mitochondrion

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GO molecular function

GO:0030145 - manganese ion binding

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GO:0070006 - metalloaminopeptidase activity

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00557Peptidase_M24Pept_M24PFAM
PF05195AMP_NAminopep_P_NPFAM
cd01087ProlidaseCDD
PS00491PROLINE_PEPTIDASEPeptidase_M24B_aminopep-P_CSPROSITE_PATTERNS
SM01011AMP_N_2Aminopep_P_NSMART
SSF55920Creatinase/aminopeptidaseCreatinase/aminopeptidase-likeSUPERFAMILY
SSF53092Creatinase/prolidase N-terminal domainCreatin/AminoP/Spt16_NSUPERFAMILY
G3DSA:3.40.350.10Creatin/AminoP/Spt16_NGENE3D
G3DSA:3.90.230.10Creatinase/methionine aminopeptidase superfamilyCreatinase/aminopeptidase-likeGENE3D
PTHR43226XAA-PRO AMINOPEPTIDASE 3X-Pro_dipept-likePANTHER

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:22495024 - Processing peptidases in mitochondria and chloroplasts.
Teixeira PF et al. Biochim Biophys Acta 2013 Feb;1833(2):360-70
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
GO_REF:0000002 - Comments
PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.
Idiris A et al. Yeast 2006 Jan 30;23(2):83-99
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531