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protein coding gene - SPAC12B10.08c - mitochondrial tRNA(Ile)-lysidine synthetase-like protein

Gene summary

Systematic ID
SPAC12B10.08c
Product
mitochondrial tRNA(Ile)-lysidine synthetase-like protein
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10441
ORFeome ID
50/50G03
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome I: 4586309..4588423 reverse strand

Annotation

Comment

PBO:0122372 - TilS specifically acts on tRNA isoleucine with a CAU anticodon, which S. pombe does not have

GO cellular component

GO:0005739 - mitochondrion

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF01171ATP_bind_3TilS/TtcA_NPfam
cd01992TilS_NtRNA_Ile_lys_synt_NCDD
G3DSA:3.40.50.620Rossmann-like_a/b/a_foldCATH-Gene3D
SSF52402SUPERFAMILY
PTHR43033tRNA_Ile_lys_syntPANTHER
TIGR02432lysidine_TilS_NtRNA_Ile_lys_synt_NNCBIFAM
MF_01161tRNA_Ile_lys_synttRNA_Ile_lys_syntHAMAP

Orthologs

References / Literature

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24223771 - New insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cells.
Mojardín L et al. PLoS One 2013;8(11):e78172