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protein coding gene - mrpl6 (SPAC12G12.08) - mitochondrial ribosomal protein subunit L6

Gene summary

Standard name
mrpl6
Systematic ID
SPAC12G12.08
Product
mitochondrial ribosomal protein subunit L6
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mrpl16, mrpl1602
UniProt ID
Q09865
ORFeome ID
42/42F03
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 333178..334564 reverse strand

Annotation

GO biological process

GO:0032543 - mitochondrial translation

References:

GO cellular component

GO:0005762 - mitochondrial large ribosomal subunit

References:

GO molecular function

GO:0019843 - rRNA binding

References:

GO:0003735 - structural constituent of ribosome

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002199 - inviable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0091263 - until Jan-28-2019 this was erroneously annotated as mrpl1602

Protein features

IDNameInterPro nameDB name
PF00347Ribosomal_L6Ribosomal_uL6_a/b-domPfam
PS00525RIBOSOMAL_L6_1Ribosomal_uL6_CSPROSITE patterns
PR00059RIBOSOMALL6Ribosomal_uL6_bactPRINTS
G3DSA:3.90.930.12:FF:000006CATH-FunFam
G3DSA:3.90.930.12Ribosomal_uL6-like_a/b-dom_sfCATH-Gene3D
SSF56053Ribosomal_uL6-like_a/b-dom_sfSUPERFAMILY
PTHR11655Ribosomal_uL6-likePANTHER
PIRSF002162Ribosomal_L6Ribosomal_uL6-likePIRSF

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40063661 - Fission yeast Caprin protein is required for efficient heterochromatin establishment.
Zhang H et al. PLoS Genet 2025 Mar 10;21(3):e1011620
GO_REF:0000002 - Comments