protein coding gene - cid14 (SPAC12G12.13c) - TRAMP complex poly(A) polymerase subunit Cid14

Gene summary

Standard name

cid14

Systematic ID

SPAC12G12.13c

Product

TRAMP complex poly(A) polymerase subunit Cid14

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9UTN3

ORFeome ID

26/26B12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 321805..324129 forward strand

Annotation

Protein features

Orthologs

• TENT4A (HGNC:16705) Homo sapiens
• TENT4B (HGNC:30758) Homo sapiens
• cid14 (SJAG_01176) Schizosaccharomyces japonicus
• TRF5 (YNL299W) Saccharomyces cerevisiae
• PAP2 (YOL115W) Saccharomyces cerevisiae

References / Literature

PMID:19693008 - Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs.

Zofall M et al. Nature 2009 Sep 17;461(7262):419-22

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21892171 - Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.

Reyes-Turcu FE et al. Nat Struct Mol Biol 2011 Sep 04;18(10):1132-8

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:20129053 - The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs.

Lemay JF et al. Mol Cell 2010 Jan 15;37(1):34-45

PMID:20512112 - Importance of polyadenylation in the selective elimination of meiotic mRNAs in growing S. pombe cells.

Yamanaka S et al. EMBO J 2010 Jul 07;29(13):2173-81

PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Zhang K et al. Science 2011 Mar 25;331(6024):1624-7

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:26518661 - The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.

Sadeghi L et al. EMBO Rep 2015 Dec;16(12):1673-87

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.

Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:25989903 - The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome.

Zhou Y et al. Nat Commun 2015 May 20;6:7050

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:20622014 - Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.

St-André O et al. J Biol Chem 2010 Sep 03;285(36):27859-68

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:17512405 - RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing.

Bühler M et al. Cell 2007 May 18;129(4):707-21

PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.

Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415

PMID:22965128 - The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression.

Larochelle M et al. Nucleic Acids Res 2012 Nov 01;40(20):10240-53

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:30652128 - Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription.

Okita AK et al. Commun Biol 2019;2:17

PMID:25240800 - The RNA exosome promotes transcription termination of backtracked RNA polymerase II.

Lemay JF et al. Nat Struct Mol Biol 2014 Oct;21(10):919-26

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:18025105 - Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing.

Wang SW et al. Mol Cell Biol 2008 Jan;28(2):656-65

PMID:22683269 - HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts.

Keller C et al. Mol Cell 2012 Jul 27;47(2):215-27

PMID:31980821 - Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells.

Maestroni L et al. Nucleic Acids Res 2020 Apr 06;48(6):3029-3041

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:26438724 - H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein.

Stunnenberg R et al. EMBO J 2015 Nov 12;34(22):2789-803

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:40185772 - A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors.

Leroy E et al. Nat Commun 2025 Apr 05;16(1):3250

PMID:26890608 - A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Gaspa L et al. Cell Cycle 2016;15(5):720-9

PMID:39358553 - Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.

Anver S et al. EMBO Rep 2024 Oct 02;

PMID:22139915 - The telomeric transcriptome of Schizosaccharomyces pombe.

Bah A et al. Nucleic Acids Res 2012 Apr;40(7):2995-3005

PMID:28541282 - Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.

Pisacane P et al. Nat Commun 2017 May 25;8:15332

PMID:20403971 - Proteomic and functional analysis of the noncanonical poly(A) polymerase Cid14.

Keller C et al. RNA 2010 Jun;16(6):1124-9

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26213367 - Human Mpn1 promotes post-transcriptional processing and stability of U6atac.

Shchepachev V et al. FEBS Lett 2015 Aug 19;589(18):2417-23

PMID:29914874 - Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.

Atkinson SR et al. RNA 2018 Sep;24(9):1195-1213

PMID:16478992 - Requirement of fission yeast Cid14 in polyadenylation of rRNAs.

Win TZ et al. Mol Cell Biol 2006 Mar;26(5):1710-21

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:35901126 - Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species.

Tasak M et al. PLoS Genet 2022 Jul;18(7):e1010215

PMID:20178743 - Dicer-independent primal RNAs trigger RNAi and heterochromatin formation.

Halic M et al. Cell 2010 Feb 19;140(4):504-16

PMID:21981922 - A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein.

Lemieux C et al. Mol Cell 2011 Oct 07;44(1):108-19