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protein coding gene - SPAC12G12.16c - Fen1 family nuclease, XP-G family

Gene summary

Systematic ID
SPAC12G12.16c
Product
Fen1 family nuclease, XP-G family
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC18B11.01c
UniProt ID
Q09708
ORFeome ID
24/24A09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 315608..317585 forward strand

Annotation

Disease association

MONDO:0019600 - xeroderma pigmentosum

References:

GO biological process

GO:0000724 - double-strand break repair via homologous recombination

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005634 - nucleus

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GO molecular function

GO:0035312 - 5'-3' DNA exonuclease activity

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GO:0017108 - 5'-flap endonuclease activity

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GO:0003677 - DNA binding

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Protein features

PBO:0111762 - XP-G family

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003938 - increased cell population growth during glucose starvation

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Genotypes:

FYPO:0009052 - increased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000111 - sensitive to rapamycin

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00752XPG_NXPG_DNA_repair_NPfam
PF00867XPG_IXPG-I_domPfam
cd09897H3TH_FEN1-XPG-likeCDD
SM00279HhH2HhH2SMART
SM00484XPGIXPG-I_domSMART
SM00485XPGNXPG_DNA_repair_NSMART
PR00853XPGRADSUPERXPG/Rad2PRINTS
G3DSA:1.10.150.20CATH-Gene3D
G3DSA:3.40.50.1010CATH-Gene3D
SSF478075-3_exonuclease_C_sfSUPERFAMILY
SSF88723PIN-like_dom_sfSUPERFAMILY
PTHR11081XPG/Rad2PANTHER
CoilCOILS

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000003 - Disease Association Curation
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83