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protein coding gene - hat1 (SPAC139.06) - histone acetyltransferase Hat1

Gene summary

Standard name
hat1
Systematic ID
SPAC139.06
Product
histone acetyltransferase Hat1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC23C4.01, kat1
UniProt ID
Q9UTM7
ORFeome ID
44/44G05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1030220..1031941 forward strand

Annotation

GO biological process

GO:0031509 - subtelomeric heterochromatin formation

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GO cellular component

GO:0000785 - chromatin

References:

GO:0140445 - chromosome, telomeric repeat region

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GO:0005737 - cytoplasm

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GO:0000123 - histone acetyltransferase complex

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GO:0005634 - nucleus

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GO molecular function

GO:0042393 - histone binding

References:

GO:0043997 - histone H4K12 acetyltransferase activity

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GO:0043995 - histone H4K5 acetyltransferase activity

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GO:0043996 - histone H4K8 acetyltransferase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004604 - decreased chromatin silencing at subtelomere

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Genotypes:

FYPO:0005315 - increased chromatin silencing at centromere central core

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Genotypes:

FYPO:0005316 - increased histone H4-K12 acetylation at subtelomere during vegetative growth

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Genotypes:

FYPO:0007631 - increased histone H4-K12 acetylation during vegetative growth

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Genotypes:

FYPO:0006752 - increased histone H4-K16 acetylation at subtelomeric heterochromatin during vegetative growth

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Genotypes:

FYPO:0007315 - increased histone H4-K8 acetylation at subtelomeric heterochromatin during vegetative growth

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Genotypes:

FYPO:0004742 - normal chromatin silencing at centromere outer repeat

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Genotypes:

FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

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Genotypes:

FYPO:0000242 - normal growth on ammonia nitrogen source

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0000243 - normal growth on proline nitrogen source

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Genotypes:

FYPO:0001839 - normal minichromosome loss

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Genotypes:

FYPO:0003362 - normal protein acetylation during vegetative growth

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00583Acetyltransf_1GNAT_domPfam
PF10394Hat1_NHat1_NPfam
PF21184HAT1_C_fungPfam
cd04301NAT_SFCDD
G3DSA:3.40.630.30:FF:000114CATH-FunFam
G3DSA:1.10.10.390Hist_AcTrfase_HAT1_CCATH-Gene3D
G3DSA:3.40.630.30CATH-Gene3D
G3DSA:3.90.360.10Hat1_N_sfCATH-Gene3D
SSF55729Acyl_CoA_acyltransferaseSUPERFAMILY
PTHR12046Hist_AcTrfase_B-typ_cat-suPANTHER
PIRSF038084HAT-B_catHist_AcTrfase_B-typ_cat-suPIRSF

Orthologs

References / Literature

PMID:22771823 - Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.
Tong K et al. Eukaryot Cell 2012 Sep;11(9):1095-103
PMID:17052979 - Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.
Benson LJ et al. J Biol Chem 2007 Jan 12;282(2):836-42
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24774534 - Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.
Hayashi T et al. Genes Cells 2014 Jul;19(7):541-54
PMID:23091701 - Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.
Nakamura T et al. Open Biol 2012 Sep;2(9):120117
PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000002 - Comments
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.
Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:20299449 - A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.
Xhemalce B et al. Genes Dev 2010 Apr 01;24(7):647-52
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20404084 - Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase.
Kaufmann I et al. Mol Cell Biol 2010 Jul;30(13):3396-410
PMID:21295010 - Mitochondrial localization of fission yeast manganese superoxide dismutase is required for its lysine acetylation and for cellular stress resistance and respiratory growth.
Takahashi H et al. Biochem Biophys Res Commun 2011 Mar 04;406(1):42-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:24909977 - A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.
Pai CC et al. Nat Commun 2014 Jun 09;5:4091
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:26518661 - The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.
Sadeghi L et al. EMBO Rep 2015 Dec;16(12):1673-87
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.
Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:24789708 - Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.
Subramanian L et al. Open Biol 2014 Apr 30;4(4):140043