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protein coding gene - mre11 (SPAC13C5.07) - Mre11 nuclease

Gene summary

Standard name
mre11
Systematic ID
SPAC13C5.07
Product
Mre11 nuclease
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rad32
UniProt ID
Q09683
ORFeome ID
40/40H02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 436179..439980 forward strand

Annotation

Disease association

MONDO:0024557 - ataxia-telangiectasia-like disorder 1

References:

MONDO:0005071 - nervous system disorder

References:

GO biological process

GO:0000729 - DNA double-strand break processing

References:

GO:0006302 - double-strand break repair

References:

GO:1990918 - double-strand break repair involved in meiotic recombination

References:

GO:0000724 - double-strand break repair via homologous recombination

References:

GO:0006303 - double-strand break repair via nonhomologous end joining

References:

GO:0042138 - meiotic DNA double-strand break formation

References:

GO:0031573 - mitotic intra-S DNA damage checkpoint signaling

References:

GO:0007131 - reciprocal meiotic recombination

References:

GO:0000723 - telomere maintenance

References:

GO cellular component

GO:0140445 - chromosome, telomeric repeat region

References:

GO:0030870 - Mre11 complex

References:

GO:0035861 - site of double-strand break

References:

GO molecular function

GO:0045027 - DNA end binding

References:

GO:0008311 - double-stranded DNA 3'-5' DNA exonuclease activity

References:

GO:0030145 - manganese ion binding

References:

GO:0004518 - nuclease activity

References:

GO:0005515 - protein binding

References:

GO:0000014 - single-stranded DNA endodeoxyribonuclease activity

References:

GO:0000403 - Y-form DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0002472 - abolished histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002597 - abolished histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0002471 - abolished protein phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0004262 - abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002702 - circularized chromosome

References:

Genotypes:

FYPO:0002907 - circularized chromosome during mitotic G1 phase

References:

Genotypes:

FYPO:0006687 - decreased DNA double-strand break processing during double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0004867 - decreased histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0005433 - decreased meiotic recombination at hotspot

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0005434 - globally decreased meiotic recombination

References:

Genotypes:

FYPO:0005618 - increased duration of meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0006872 - increased histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002596 - increased histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002475 - increased protein localization to double-strand break site

References:

Genotypes:

FYPO:0005402 - increased telomeric 3' overhang length during vegetative growth

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0001178 - loss of viability upon nitrogen starvation

References:

Genotypes:

FYPO:0004286 - normal double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0004229 - normal growth during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

References:

Genotypes:

FYPO:0005954 - normal histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002601 - normal histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0005936 - normal intragenic meiotic recombination frequency

References:

Genotypes:

FYPO:0002554 - normal protein localization to double-strand break site

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0002905 - normal telomere maintenance

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0005549 - normal viability upon nitrogen starvation

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0003858 - sensitive to etoposide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0005919 - sensitive to TOP-53

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0005403 - telomeric 3' overhang absent during vegetative growth

References:

Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001352 - abnormal chromatin organization during vegetative growth

References:

Genotypes:

FYPO:0005913 - abnormal chromatin remodeling during meiosis I

References:

Genotypes:

FYPO:0000777 - abnormal double-strand break repair during vegetative growth

References:

Genotypes:

FYPO:0003661 - abnormal double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0005268 - abnormal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0000006 - abnormal mitotic DNA damage checkpoint

References:

Genotypes:

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0000913 - abnormal sporulation resulting in formation of ascus containing non-uniform spores

References:

Genotypes:

FYPO:0001118 - abnormal vegetative cell morphology

References:

Genotypes:

FYPO:0005453 - abolished break-induced loss of heterozygosity via chromosomal translocation

References:

Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0005140 - abolished meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0003164 - abolished nuclease activity

References:

Genotypes:

FYPO:0003486 - abolished protein localization to double-strand break site

References:

Genotypes:

FYPO:0005616 - abolished protein phosphorylation during cellular response to bleomycin

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0005451 - decreased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

References:

Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0006687 - decreased DNA double-strand break processing during double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0003660 - decreased double-strand break repair during vegetative growth

References:

Genotypes:

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0005408 - decreased duration of mitotic S phase during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000470 - decreased mating type switching

References:

Genotypes:

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0000485 - decreased meiotic recombination

References:

Genotypes:

FYPO:0005431 - decreased mitotic recombination at hotspot

References:

Genotypes:

FYPO:0000218 - decreased Mre11 complex assembly

References:

Genotypes:

FYPO:0001382 - decreased protein kinase activity

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002474 - decreased protein localization to double-strand break site

References:

Genotypes:

FYPO:0002897 - decreased protein phosphorylation during cellular response to DNA damage

References:

Genotypes:

FYPO:0002470 - decreased protein phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0004261 - decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0005452 - increased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0000657 - increased DNA binding

References:

Genotypes:

FYPO:0005618 - increased duration of meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0003662 - increased error-free double-strand break repair

References:

Genotypes:

FYPO:0007392 - increased loss of disomic chromosome 3

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0001861 - increased minichromosome loss upon segregation during vegetative growth

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0002475 - increased protein localization to double-strand break site

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0001927 - normal cell cycle regulation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0003555 - normal chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0001033 - normal double-strand break repair

References:

Genotypes:

FYPO:0004286 - normal double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0006319 - normal extent of DNA resection during replication fork processing

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0002169 - normal growth during cellular response to gamma radiation

References:

Genotypes:

FYPO:0004229 - normal growth during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0007035 - normal growth on 5-fluorouracil

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

References:

Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

References:

Genotypes:

FYPO:0005954 - normal histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0005936 - normal intragenic meiotic recombination frequency

References:

Genotypes:

FYPO:0005136 - normal meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0005373 - normal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0005299 - normal mitotic G2 DNA damage checkpoint during cellular response to UV

References:

Genotypes:

FYPO:0003075 - normal protein kinase activity

References:

Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0005236 - normal protein localization to chromatin at stalled replication fork

References:

Genotypes:

FYPO:0002554 - normal protein localization to double-strand break site

References:

Genotypes:

FYPO:0002887 - normal protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0004252 - normal regulation of DNA replication during replication fork arrest

References:

Genotypes:

FYPO:0004993 - normal spore germination frequency

References:

Genotypes:

FYPO:0002052 - normal sporulation frequency

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0003503 - normal vegetative cell length

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0005549 - normal viability upon nitrogen starvation

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0000327 - resistance to trichostatin A

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001098 - sensitive to 4-nitroquinoline N-oxide

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000102 - sensitive to cisplatin

References:

Genotypes:

FYPO:0001245 - sensitive to cobalt

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0000266 - sensitive to DNA damaging agents

References:

Genotypes:

FYPO:0003559 - sensitive to doxorubicin

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0003858 - sensitive to etoposide

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0005919 - sensitive to TOP-53

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0005624 - sensitive to UV during mitotic S phase

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0000646 - swollen vegetative cell

References:

Genotypes:

FYPO:0005455 - telomere assembly at double-strand break site

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04152Mre11_DNA_bindMre11_DNA-bdPFAM
PF00149MetallophosCalcineurin-like_PHPPFAM
cd00840MPP_Mre11_NMre11_NCDD
SM01347Mre11_DNA_bind_2Mre11_DNA-bdSMART
G3DSA:3.30.110.110:FF:000004FUNFAM
G3DSA:3.60.21.10:FF:000011FUNFAM
SSF56300Metallo-dependent phosphatasesMetallo-depent_PP-likeSUPERFAMILY
G3DSA:3.30.110.110Mre11, capping domainMre11_capping_domGENE3D
G3DSA:3.60.21.10Metallo-depent_PP-likeGENE3D
PTHR10139DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11PANTHER
PIRSF000882DSB_repair_MRE11Mre11PIRSF
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMOBIDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
TIGR00583mre11Mre11NCBIFAM

Orthologs

References / Literature

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.
Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595
PMID:23080121 - Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Limbo O et al. Nucleic Acids Res 2012 Dec;40(22):11435-49
PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.
Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)
PMID:23211746 - Initiation of DNA damage responses through XPG-related nucleases.
Kuntz K et al. EMBO J 2013 Jan 23;32(2):290-302
PMID:21408210 - SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.
Heideker J et al. PLoS Genet 2011 Mar;7(3):e1001320
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:22705791 - Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Schiller CB et al. Nat Struct Mol Biol 2012 Jun 17;19(7):693-700
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:28292918 - Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe .
Li Y et al. Genetics 2017 May;206(1):481-496
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29851556 - Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.
Limbo O et al. Mol Biol Cell 2018 Jun 01;29(11):1389-1399
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:12628934 - Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.
Prudden J et al. EMBO J 2003 Mar 17;22(6):1419-30
PMID:23188080 - The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.
Reis CC et al. EMBO J 2012 Dec 12;31(24):4576-86
PMID:19470480 - Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination.
Farah JA et al. Proc Natl Acad Sci U S A 2009 Jun 09;106(23):9356-61
PMID:23335786 - Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.
Almeida H et al. Nucleic Acids Res 2013 Mar 01;41(5):3056-67
PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83
PMID:26652183 - Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.
Callegari AJ et al. Cell Cycle 2016;15(2):261-73
PMID:9651580 - The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.
Paull TT et al. Mol Cell 1998 Jun;1(7):969-79
PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52
PMID:18854158 - Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Williams RS et al. Cell 2008 Oct 03;135(1):97-109
PMID:28922417 - Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.
Sanchez A et al. PLoS Genet 2017 Sep;13(9):e1007013
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:9092625 - Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.
Shayeghi M et al. Nucleic Acids Res 1997 Mar 15;25(6):1162-9
PMID:18160711 - Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.
Subramanian L et al. Mol Cell Biol 2008 Mar;28(5):1443-55
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:18378696 - Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.
Akamatsu Y et al. Mol Cell Biol 2008 Jun;28(11):3639-51
PMID:21098122 - Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.
Limbo O et al. Mol Cell Biol 2011 Feb;31(3):573-83
PMID:12930957 - Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.
Meister P et al. Nucleic Acids Res 2003 Sep 01;31(17):5064-73
PMID:24806966 - The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.
Tsang E et al. J Cell Sci 2014 Jul 01;127(Pt 13):2983-94
PMID:33836577 - A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
Zdravković A et al. Proc Natl Acad Sci U S A 2021 Mar 16;118(11)
PMID:8594339 - Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast.
Sharples GJ et al. Mol Microbiol 1995 Sep;17(6):1215-7
PMID:31563844 - The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stability.
Sparks JL et al. DNA Repair (Amst) 2019 Nov;83:102720
PMID:12944481 - Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.
Ueno M et al. Mol Cell Biol 2003 Sep;23(18):6553-63
PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:21441914 - ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
Williams GJ et al. Nat Struct Mol Biol 2011 Apr;18(4):423-31
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