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protein coding gene - mre11 (SPAC13C5.07) - Mre11 nuclease

Gene summary

Standard name
mre11
Systematic ID
SPAC13C5.07
Product
Mre11 nuclease
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rad32
UniProt ID
Q09683
ORFeome ID
40/40H02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 436179..439980 forward strand

Annotation

Disease association

MONDO:0024557 - ataxia-telangiectasia-like disorder 1

References:

MONDO:0005071 - nervous system disorder

References:

GO biological process

GO:0000729 - DNA double-strand break processing

References:

GO:0006302 - double-strand break repair

References:

GO:1990918 - double-strand break repair involved in meiotic recombination

References:

GO:0000724 - double-strand break repair via homologous recombination

References:

GO:0006303 - double-strand break repair via nonhomologous end joining

References:

GO:0042138 - meiotic DNA double-strand break formation

References:

GO:0031573 - mitotic intra-S DNA damage checkpoint signaling

References:

GO:0007131 - reciprocal meiotic recombination

References:

GO:0000723 - telomere maintenance

References:

GO cellular component

GO:0140445 - chromosome, telomeric repeat region

References:

GO:0030870 - Mre11 complex

References:

GO:0005634 - nucleus

References:

GO:0035861 - site of double-strand break

References:

GO molecular function

GO:0045027 - DNA end binding

References:

GO:0008311 - double-stranded DNA 3'-5' DNA exonuclease activity

References:

GO:0030145 - manganese ion binding

References:

GO:0004518 - nuclease activity

References:

GO:0005515 - protein binding

References:

GO:0000014 - single-stranded DNA endonuclease activity

References:

GO:0000403 - Y-form DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0002472 - abolished histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002597 - abolished histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0002471 - abolished protein phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0004262 - abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002702 - circularized chromosome

References:

Genotypes:

FYPO:0002907 - circularized chromosome during mitotic G1 phase

References:

Genotypes:

FYPO:0006687 - decreased DNA double-strand break processing during double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0004867 - decreased histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0005433 - decreased meiotic recombination at hotspot

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0005434 - globally decreased meiotic recombination

References:

Genotypes:

FYPO:0005618 - increased duration of meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0006872 - increased histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002596 - increased histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002475 - increased protein localization to double-strand break site

References:

Genotypes:

FYPO:0005402 - increased telomeric 3' overhang length during vegetative growth

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0001178 - loss of viability upon nitrogen starvation

References:

Genotypes:

FYPO:0004286 - normal double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0004229 - normal growth during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

References:

Genotypes:

FYPO:0005954 - normal histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002601 - normal histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0005936 - normal intragenic meiotic recombination frequency

References:

Genotypes:

FYPO:0002554 - normal protein localization to double-strand break site

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0002905 - normal telomere maintenance

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0005549 - normal viability upon nitrogen starvation

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0003858 - sensitive to etoposide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0005919 - sensitive to TOP-53

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0005403 - telomeric 3' overhang absent during vegetative growth

References:

Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001352 - abnormal chromatin organization during vegetative growth

References:

Genotypes:

FYPO:0005913 - abnormal chromatin remodeling during meiosis I

References:

Genotypes:

FYPO:0000777 - abnormal double-strand break repair during vegetative growth

References:

Genotypes:

FYPO:0003661 - abnormal double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0005268 - abnormal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0000006 - abnormal mitotic DNA damage checkpoint

References:

Genotypes:

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0000913 - abnormal sporulation resulting in formation of ascus containing non-uniform spores

References:

Genotypes:

FYPO:0001118 - abnormal vegetative cell morphology

References:

Genotypes:

FYPO:0005453 - abolished break-induced loss of heterozygosity via chromosomal translocation

References:

Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0005140 - abolished meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0003164 - abolished nuclease activity

References:

Genotypes:

FYPO:0003486 - abolished protein localization to double-strand break site

References:

Genotypes:

FYPO:0005616 - abolished protein phosphorylation during cellular response to bleomycin

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0005451 - decreased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

References:

Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0006687 - decreased DNA double-strand break processing during double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0003660 - decreased double-strand break repair during vegetative growth

References:

Genotypes:

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0005408 - decreased duration of mitotic S phase during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000470 - decreased mating type switching

References:

Genotypes:

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0000485 - decreased meiotic recombination

References:

Genotypes:

FYPO:0005431 - decreased mitotic recombination at hotspot

References:

Genotypes:

FYPO:0000218 - decreased Mre11 complex assembly

References:

Genotypes:

FYPO:0001382 - decreased protein kinase activity

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002474 - decreased protein localization to double-strand break site

References:

Genotypes:

FYPO:0002897 - decreased protein phosphorylation during cellular response to DNA damage

References:

Genotypes:

FYPO:0002470 - decreased protein phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0004261 - decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0005452 - increased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0000657 - increased DNA binding

References:

Genotypes:

FYPO:0005618 - increased duration of meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0003662 - increased error-free double-strand break repair

References:

Genotypes:

FYPO:0007392 - increased loss of disomic chromosome 3

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0001861 - increased minichromosome loss upon segregation during vegetative growth

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0002475 - increased protein localization to double-strand break site

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0001927 - normal cell cycle regulation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0003555 - normal chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0001033 - normal double-strand break repair

References:

Genotypes:

FYPO:0004286 - normal double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0006319 - normal extent of DNA resection during replication fork processing

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0002169 - normal growth during cellular response to gamma radiation

References:

Genotypes:

FYPO:0004229 - normal growth during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0007035 - normal growth on 5-fluorouracil

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

References:

Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

References:

Genotypes:

FYPO:0005954 - normal histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0005936 - normal intragenic meiotic recombination frequency

References:

Genotypes:

FYPO:0005136 - normal meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0005373 - normal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0005299 - normal mitotic G2 DNA damage checkpoint during cellular response to UV

References:

Genotypes:

FYPO:0003075 - normal protein kinase activity

References:

Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0005236 - normal protein localization to chromatin at stalled replication fork

References:

Genotypes:

FYPO:0002554 - normal protein localization to double-strand break site

References:

Genotypes:

FYPO:0002887 - normal protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0004252 - normal regulation of DNA replication during replication fork arrest

References:

Genotypes:

FYPO:0004993 - normal spore germination frequency

References:

Genotypes:

FYPO:0002052 - normal sporulation frequency

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0003503 - normal vegetative cell length

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0005549 - normal viability upon nitrogen starvation

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0000327 - resistance to trichostatin A

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001098 - sensitive to 4-nitroquinoline N-oxide

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000102 - sensitive to cisplatin

References:

Genotypes:

FYPO:0001245 - sensitive to cobalt

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0000266 - sensitive to DNA damaging agents

References:

Genotypes:

FYPO:0003559 - sensitive to doxorubicin

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0003858 - sensitive to etoposide

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0005919 - sensitive to TOP-53

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0005624 - sensitive to UV during mitotic S phase

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0000646 - swollen vegetative cell

References:

Genotypes:

FYPO:0005455 - telomere assembly at double-strand break site

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00149MetallophosCalcineurin-like_PHPPfam
PF04152Mre11_DNA_bindMre11_DNA-bdPfam
cd00840MPP_Mre11_NMre11_NCDD
SM01347Mre11_DNA_bindMre11_DNA-bdSMART
G3DSA:3.30.110.110:FF:000004CATH-FunFam
G3DSA:3.60.21.10:FF:000011CATH-FunFam
G3DSA:3.30.110.110Mre11_capping_domCATH-Gene3D
G3DSA:3.60.21.10Metallo-depent_PP-likeCATH-Gene3D
SSF56300Metallo-depent_PP-likeSUPERFAMILY
PTHR10139PANTHER
PIRSF000882DSB_repair_MRE11Mre11PIRSF
TIGR00583mre11Mre11NCBIFAM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMobiDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:26368543 - Critical Function of γH2A in S-Phase.
Mejia-Ramirez E et al. PLoS Genet 2015 Sep;11(9):e1005517
PMID:18160711 - Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.
Subramanian L et al. Mol Cell Biol 2008 Mar;28(5):1443-55
PMID:18854158 - Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Williams RS et al. Cell 2008 Oct 03;135(1):97-109
PMID:24875629 - Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.
Ding L et al. G3 (Bethesda) 2014 May 28;4(8):1373-84
PMID:23211746 - Initiation of DNA damage responses through XPG-related nucleases.
Kuntz K et al. EMBO J 2013 Jan 23;32(2):290-302
PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52
PMID:12628934 - Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.
Prudden J et al. EMBO J 2003 Mar 17;22(6):1419-30
PMID:12944482 - The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint.
Chahwan C et al. Mol Cell Biol 2003 Sep;23(18):6564-73
PMID:26891792 - Calcium modulation of doxorubicin cytotoxicity in yeast and human cells.
Nguyen TT et al. Genes Cells 2016 Mar;21(3):226-40
PMID:19798055 - Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast.
Tinline-Purvis H et al. EMBO J 2009 Nov 04;28(21):3400-12
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83
PMID:12930957 - Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.
Meister P et al. Nucleic Acids Res 2003 Sep 01;31(17):5064-73
PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9
PMID:19752195 - Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.
Milman N et al. Mol Cell Biol 2009 Nov;29(22):5998-6005
PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .
Wiley DJ et al. Front Physiol 2020;11:427
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:8594339 - Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast.
Sharples GJ et al. Mol Microbiol 1995 Sep;17(6):1215-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:29635344 - Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast.
Lim KK et al. Nucleic Acids Res 2018 Jun 01;46(10):5061-5074
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:16043696 - Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe.
Ellermeier C et al. Proc Natl Acad Sci U S A 2005 Aug 02;102(31):10952-7
PMID:12861005 - Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres.
Tomita K et al. Mol Cell Biol 2003 Aug;23(15):5186-97
PMID:21931565 - Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.
Langerak P et al. PLoS Genet 2011 Sep;7(9):e1002271
PMID:16371652 - Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast.
Marchetti MA et al. J Cell Sci 2006 Jan 01;119(Pt 1):124-31
PMID:23080121 - Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Limbo O et al. Nucleic Acids Res 2012 Dec;40(22):11435-49
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:31563844 - The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stability.
Sparks JL et al. DNA Repair (Amst) 2019 Nov;83:102720
PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.
Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89
PMID:21429938 - Functional interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex.
Bonfils S et al. J Cell Sci 2011 Apr 15;124(Pt 8):1328-38
PMID:28552615 - SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
Wei Y et al. Mol Cell 2017 Jun 01;66(5):581-596.e6
PMID:17724078 - Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.
Cullen JK et al. Mol Cell Biol 2007 Nov;27(21):7745-57
PMID:28292918 - Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe .
Li Y et al. Genetics 2017 May;206(1):481-496
PMID:15964794 - ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.
You Z et al. Mol Cell Biol 2005 Jul;25(13):5363-79
PMID:26791325 - Predicting chemotherapeutic drug combinations through gene network profiling.
Nguyen TT et al. Sci Rep 2016 Jan 21;6:18658
PMID:18388861 - Mus81 is essential for sister chromatid recombination at broken replication forks.
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