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protein coding gene - msh1 (SPAC13F5.01c) - mitochondrial MutS protein Msh1

Gene summary

Standard name
msh1
Systematic ID
SPAC13F5.01c
Product
mitochondrial MutS protein Msh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC23C11.18c
UniProt ID
O13921
ORFeome ID
47/47D11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2169036..2172147 reverse strand

Annotation

GO biological process

GO:0006298 - mismatch repair

References:

GO:0043504 - mitochondrial DNA repair

References:

GO cellular component

GO:0000262 - mitochondrial chromosome

References:

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

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GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0140664 - ATP-dependent DNA damage sensor activity

References:

GO:0030983 - mismatched DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF00488MutS_VDNA_mismatch_repair_MutS_CPFAM
PF05192MutS_IIIDNA_mismatch_repair_MutS_corePFAM
PF05188MutS_IIDNA_mmatch_repair_MutS_con_domPFAM
PF01624MutS_IDNA_mismatch_repair_MutS-lik_NPFAM
PS00486DNA_MISMATCH_REPAIR_2DNA_mismatch_repair_MutS_CPROSITE_PATTERNS
SM00534mutATP5DNA_mismatch_repair_MutS_CSMART
SM00533DNAendDNA_mismatch_repair_MutS_coreSMART
G3DSA:1.10.1420.10:FF:000042FUNFAM
G3DSA:1.10.1420.10:FF:000046FUNFAM
G3DSA:3.40.50.300:FF:001238FUNFAM
SSF53150DNA repair protein MutS, domain IIMutS_con_dom_sfSUPERFAMILY
SSF55271DNA repair protein MutS, domain IDNA_mismatch_repair_MutS_NSUPERFAMILY
SSF48334DNA repair protein MutS, domain IIIDNA_mismatch_repair_MutS_sfSUPERFAMILY
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.1170.10DNA repair protein MutS, domain IDNA_mismatch_repair_MutS_NGENE3D
G3DSA:1.10.1420.10GENE3D
G3DSA:3.30.420.110MutS, connector domainMutS_con_dom_sfGENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR11361DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBERMutSPANTHER
PIRSF037677Msh6DNA_mismatch_repair_MutS/MSHPIRSF
CoilCoilCOILS

Orthologs

References / Literature

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
GO_REF:0000002 - Comments
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.
McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23028377 - Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast.
Choi ES et al. PLoS Genet 2012 Sep;8(9):e1002985