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protein coding gene - trs33 (SPAC13G6.05c) - TRAPPI,II,III complex subunit Trs33

Gene summary

Standard name
trs33
Systematic ID
SPAC13G6.05c
Product
TRAPPI,II,III complex subunit Trs33
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q09784
ORFeome ID
17/17B08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 180903..182238 reverse strand

Annotation

Disease association

MONDO:0060640 - neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy

References:

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO:0006891 - intra-Golgi vesicle-mediated transport

References:

GO:0016236 - macroautophagy

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GO cellular component

GO:0005801 - cis-Golgi network

References:

GO:0005802 - trans-Golgi network

References:

GO:1990070 - TRAPPI protein complex

References:

GO:1990071 - TRAPPII protein complex

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GO:1990072 - TRAPPIII protein complex

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF04051TRAPPTRAPP_componentPfam
cd14944TRAPPC6A_Trs33TRAPPC6/Trs33CDD
G3DSA:3.30.1380.20CATH-Gene3D
SSF111126NO_sig/Golgi_transp_ligand-bdSUPERFAMILY
PTHR12817TRAPPC6/Trs33PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31