protein coding gene - erg7 (SPAC13G7.01c) - lanosterol synthase Erg7

Gene summary

Standard name: erg7
Systematic ID: SPAC13G7.01c
Product: lanosterol synthase Erg7
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPAC4G9.21c
UniProt ID: Q10231
ORFeome ID: 38/38C04
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 2292636..2295282 reverse strand

Annotation

Complementation

PBO:0016532 - functionally complements S. cerevisiae YHR072W

References:

PMID:8604986

Disease association

MONDO:0030009 - alopecia-intellectual disability syndrome 4

References:

PB_REF:0000006

MONDO:0014673 - cataract 44

References:

PB_REF:0000006

MONDO:0032649 - hypotrichosis 14

References:

PB_REF:0000006

GO biological process

GO:0006696 - ergosterol biosynthetic process

References:

GO_REF:0000033

GO:0016104 - triterpenoid biosynthetic process

References:

GO_REF:0000002

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005783 - endoplasmic reticulum

References:

GO_REF:0000024

GO:0005811 - lipid droplet

References:

GO_REF:0000033

GO molecular function

GO:0000250 - lanosterol synthase activity

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:39367033

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PMID:33313903

PomGeneEx:0000011 - RNA level increased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0001991 - inviable after spore germination, without cell division

References:

PMID:23697806

Genotypes:

erg7delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

erg7delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

erg7delta

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

PMID:23697806

Genotypes:

erg7delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF13249	SQHop_cyclase_N	SQ_cyclase_N	PFAM
PF13243	SQHop_cyclase_C	SQ_cyclase_C	PFAM
cd02892	SQCY_1	Squalene_cyclase	CDD
PS01074	TERPENE_SYNTHASES	Terpene_synthase_CS	PROSITE_PATTERNS
G3DSA:1.50.10.20:FF:000003			FUNFAM
SSF48239	Terpenoid cyclases/Protein prenyltransferases	Terpenoid_cyclase/PrenylTrfase	SUPERFAMILY
G3DSA:1.50.10.20			GENE3D
G3DSA:6.20.120.20			GENE3D
PTHR11764	TERPENE CYCLASE/MUTASE FAMILY MEMBER	Squalene_cyclase	PANTHER
TIGR01787	squalene_cyclas	Squalene_cyclase	NCBIFAM
SFLDG01016	Prenyltransferase_Like_2	Squalene_cyclase	SFLD

Orthologs

LSS (HGNC:6708) Homo sapiens
erg7 (SJAG_00624) Schizosaccharomyces japonicus
ERG7 (YHR072W) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:8604986 - Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues.: Corey EJ et al. Biochem Biophys Res Commun 1996 Feb 15;219(2):327-31
GO_REF:0000002 - Comments
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)