PomBase home

protein coding gene - teb1 (SPAC13G7.10) - DNA-binding transcription factor Teb1

Gene summary

Standard name
teb1
Systematic ID
SPAC13G7.10
Product
DNA-binding transcription factor Teb1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug152, tay1, spX
UniProt ID
Q10274
ORFeome ID
22/22H12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2313649..2315160 forward strand

Annotation

Comment

PBO:0091378 - binds with high affinity to mammalian-type 5'-TTAGGG-3' telomeric repeats, and with very low affinity to less stringently conserved S. pombe telomeric repeats

References:

GO biological process

GO:0006357 - regulation of transcription by RNA polymerase II

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

References:

GO:0005515 - protein binding

References:

GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

References:

GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding

References:

GO:0043565 - sequence-specific DNA binding

References:

GO:0003712 - transcription coregulator activity

References:

GO:0042162 - telomeric repeat DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein features

PBO:0111844 - Myb family

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000640 - abnormal chromatin silencing at centromere central core

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0004907 - decreased chromatin binding at histone promoter

References:

Genotypes:

FYPO:0004906 - decreased level of histone gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0004905 - decreased level of iron homeostasis gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0004711 - decreased level of translation gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0004904 - decreased protein localization to centromere central core during vegetative growth

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0002262 - inviable after spore germination, multiple cell divisions, elongated cell

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

FYPO:0004742 - normal chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0003555 - normal chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00249Myb_DNA-bindingSANT/MybPFAM
cd11660SANT_TRFCDD
PS50090MYB_LIKESANT/MybPROSITE_PROFILES
PS51294HTH_MYBMyb_domPROSITE_PROFILES
SM00717santSANT/MybSMART
G3DSA:1.10.10.60:FF:000500FUNFAM
SSF46689Homeodomain-likeHomeodomain-like_sfSUPERFAMILY
G3DSA:1.10.10.60GENE3D
PTHR46734TELOMERIC REPEAT-BINDING FACTOR 1 TERF1TRBD-Containing_ProteinPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27901072 - Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription.
Takayama Y et al. Sci Rep 2016 Nov 30;6:38111
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:10606652 - Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA.
Spink KG et al. Nucleic Acids Res 2000 Jan 15;28(2):527-33
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:10572167 - Taz1p and Teb1p, two telobox proteins in Schizosaccharomyces pombe, recognize different telomere-related DNA sequences.
Vassetzky NS et al. Nucleic Acids Res 1999 Dec 15;27(24):4687-94
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20923774 - Tay1 protein, a novel telomere binding factor from Yarrowia lipolytica.
Kramara J et al. J Biol Chem 2010 Dec 03;285(49):38078-92
PMID:29735745 - Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1.
Schiklenk C et al. J Cell Biol 2018 Jul 02;217(7):2383-2401
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27101289 - Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins.
Sepsiova R et al. PLoS One 2016;11(4):e0154225
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23314747 - Myb-domain protein Teb1 controls histone levels and centromere assembly in fission yeast.
Valente LP et al. EMBO J 2013 Feb 06;32(3):450-60
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115