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protein coding gene - eki1 (SPAC13G7.12c) - choline/ethanolamine kinase Eki1

Gene summary

Standard name
eki1
Systematic ID
SPAC13G7.12c
Product
choline/ethanolamine kinase Eki1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10276
ORFeome ID
21/21C01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2315455..2318313 reverse strand

Annotation

Disease association

MONDO:0011246 - megaconial type congenital muscular dystrophy

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MONDO:0859282 - neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures

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GO biological process

GO:0006657 - CDP-choline pathway

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GO:0006646 - phosphatidylethanolamine biosynthetic process

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0004103 - choline kinase activity

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GO:0004305 - ethanolamine kinase activity

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Modification

MOD:01148 - ubiquitinylated lysine

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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FYPO:0000067 - resistance to brefeldin A

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FYPO:0000073 - resistance to caffeine

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FYPO:0001453 - resistance to ethanol

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FYPO:0009070 - resistance to itraconazole

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FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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FYPO:0000104 - sensitive to cycloheximide

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FYPO:0007931 - sensitive to egtazic acid

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FYPO:0000088 - sensitive to hydroxyurea

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FYPO:0001719 - sensitive to lithium

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FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

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FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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FYPO:0001457 - sensitive to tunicamycin

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FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF01633Choline_kinasePFAM
PF04428Choline_kin_NCholine_kin_NPFAM
cd05157ETNK_eukCDD
SSF56112Protein kinase-like (PK-like)Kinase-like_dom_sfSUPERFAMILY
G3DSA:3.30.200.20Phosphorylase Kinase; domain 1GENE3D
G3DSA:3.90.1200.10GENE3D
PTHR22603CHOLINE/ETHANOALAMINE KINASEPANTHER

Orthologs

References / Literature

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000051 - S. pombe keyword mapping
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71