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protein coding gene - cox1101 (SPAC1420.04c) - cytochrome c oxidase copper chaperone Cox1101/ mitochondrial ribosome assembly protein Rsm22 fusion protein

Gene summary

Standard name
cox1101
Systematic ID
SPAC1420.04c
Product
cytochrome c oxidase copper chaperone Cox1101/ mitochondrial ribosome assembly protein Rsm22 fusion protein
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
cox11, SPAPB17E12.01c
UniProt ID
Q9UTM2
ORFeome ID
51/51A06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1267830..1270166 reverse strand

Annotation

Comment

PBO:0000877 - target of TIM23 translocase

References:

Disease association

MONDO:0859520 - mitochondrial complex IV deficiency, nuclear type 23

References:

MONDO:0016387 - mitochondrial oxidative phosphorylation disorder

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GO biological process

GO:0033617 - mitochondrial respiratory chain complex IV assembly

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GO:0032543 - mitochondrial translation

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GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0016531 - copper chaperone activity

References:

GO:0005507 - copper ion binding

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GO:0051536 - iron-sulfur cluster binding

References:

GO:0008168 - methyltransferase activity

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Genome organisation

PBO:0000228 - domain combination not observed in other organisms

References:

PBO:0000229 - tandem fusion protein

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Protein sequence feature

SO:0100011 - cleaved_peptide_region

References:

SO:0001808 - mitochondrial_targeting_signal

References:

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF09243Rsm22Ribosomal_Rsm22-likePFAM
PF04442CtaG_Cox11Cyt_c_oxidase_assmbl_CtaGPFAM
G3DSA:2.60.370.10:FF:000001FUNFAM
SSF110111Ctag/Cox11CtaG/Cox11_dom_sfSUPERFAMILY
G3DSA:2.60.370.10Ctag/Cox11CtaG/Cox11_dom_sfGENE3D
PTHR21320CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATEDPANTHER
MF_00155CtaGCyt_c_oxidase_assmbl_CtaGHAMAP
NF003465PRK05089.1NCBIFAM

Orthologs

References / Literature

GO_REF:0000051 - S. pombe keyword mapping
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:16835444 - Sequential processing of a mitochondrial tandem protein: insights into protein import in Schizosaccharomyces pombe.
Khalimonchuk O et al. Eukaryot Cell 2006 Jul;5(7):997-1006
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000043 - Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:38068960 - Novel COX11 Mutations Associated with Mitochondrial Disorder: Functional Characterization in Patient Fibroblasts and Saccharomyces cerevisiae .
Caron-Godon CA et al. Int J Mol Sci 2023 Nov 23;24(23)