protein coding gene - gpn2 (SPAC144.07c) - conserved GTPase Gpn2

Gene summary

Standard name: gpn2
Systematic ID: SPAC144.07c
Product: conserved GTPase Gpn2
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UTL7
ORFeome ID: 13/13C11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 4667119..4668753 reverse strand

Annotation

GO biological process

GO:0006606 - protein import into nucleus

References:

GO_REF:0000024

GO cellular component

GO:0005737 - cytoplasm

References:

PMID:22146723

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0003924 - GTPase activity

References:

GO_REF:0000033

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:24763107

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

PMID:23697806

Genotypes:

gpn2delta

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

PMID:23697806

Genotypes:

gpn2delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

gpn2delta

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF03029	ATP_bind_1	Gpn	PFAM
cd17871	GPN2	Gpn2	CDD
G3DSA:3.40.50.300:FF:000338			FUNFAM
SSF52540	P-loop containing nucleoside triphosphate hydrolases	P-loop_NTPase	SUPERFAMILY
G3DSA:3.40.50.300		P-loop_NTPase	GENE3D
PTHR21231	XPA-BINDING PROTEIN 1-RELATED	Gpn	PANTHER

Orthologs

GPN2 (HGNC:25513) Homo sapiens
gpn2 (SJAG_00065) Schizosaccharomyces japonicus
GPN2 (YOR262W) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22146723 - Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.: Ikebe C et al. Biosci Biotechnol Biochem 2011;75(12):2364-70
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6