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protein coding gene - sfc2 (SPAC144.09c) - transcription factor TFIIIA

Gene summary

Standard name
sfc2
Systematic ID
SPAC144.09c
Product
transcription factor TFIIIA
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTL5
ORFeome ID
18/18E04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4669627..4671248 reverse strand

Annotation

GO biological process

GO:0006384 - transcription initiation at RNA polymerase III promoter

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0008097 - 5S rRNA binding

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GO:0003677 - DNA binding

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GO:0000995 - RNA polymerase III general transcription initiation factor activity

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Protein features

PBO:0111745 - zf-C2H2 type

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PBO:0111743 - zinc finger protein

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Qualitative gene expression

PomGeneEx:0000026 - ribosomal density increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000117 - abnormal septum assembly

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Genotypes:

FYPO:0000659 - abolished DNA binding

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Genotypes:

FYPO:0000046 - decreased cell population growth

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Genotypes:

FYPO:0002876 - decreased transcription

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Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000655 - normal DNA binding

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00096zf-C2H2Zf-C2H2_typePfam
PS00028ZINC_FINGER_C2H2_1Zf-C2H2_typePROSITE patterns
PS50157ZINC_FINGER_C2H2_2Zf-C2H2_typePROSITE profiles
SM00355ZnF_C2H2Zf-C2H2_typeSMART
G3DSA:3.30.160.60:FF:000032CATH-FunFam
G3DSA:3.30.160.60:FF:004026CATH-FunFam
G3DSA:3.30.160.60CATH-Gene3D
SSF57667Znf_C2H2_sfSUPERFAMILY
PTHR46179PANTHER

Orthologs

References / Literature

PMID:12087160 - Identification and characterization of transcription factor IIIA from Schizosaccharomyces pombe.
Schulman DB et al. Nucleic Acids Res 2002 Jul 01;30(13):2772-81
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:12888341 - Functional analysis of the novel C-terminal domains of S pombe transcription factor IIIA.
Schulman DB et al. J Mol Biol 2003 Aug 08;331(2):321-30
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.
Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:10906331 - Isolation and cloning of four subunits of a fission yeast TFIIIC complex that includes an ortholog of the human regulatory protein TFIIICbeta.
Huang Y et al. J Biol Chem 2000 Oct 06;275(40):31480-7