protein coding gene - rki1 (SPAC144.12) - ribose 5-phosphate isomerase Rki1

Gene summary

Standard name: rki1
Systematic ID: SPAC144.12
Product: ribose 5-phosphate isomerase Rki1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UTL3
ORFeome ID: 10/10F08
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 4675844..4678174 forward strand

Annotation

Disease association

MONDO:0012073 - ribose-5-P isomerase deficiency

References:

PB_REF:0000006

GO biological process

GO:0006014 - D-ribose metabolic process

References:

GO_REF:0000033

GO:0009052 - pentose-phosphate shunt, non-oxidative branch

References:

PMID:9872416

GO cellular component

GO:0005829 - cytosol

References:

GO_REF:0000111

GO molecular function

GO:0004751 - ribose-5-phosphate isomerase activity

References:

PMID:9872416

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

PMID:12161753

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

PMID:23697806

Genotypes:

rki1delta

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

PMID:23697806

Genotypes:

rki1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

rki1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF06026	Rib_5-P_isom_A	Ribose5P_isomerase_type_A	Pfam
cd01398	RPI_A	Ribose5P_isomerase_type_A	CDD
G3DSA:3.30.70.260:FF:000053			CATH-FunFam
G3DSA:3.40.50.1360:FF:000014			CATH-FunFam
G3DSA:3.30.70.260			CATH-Gene3D
G3DSA:3.40.50.1360			CATH-Gene3D
SSF100950		NagB/RpiA_transferase-like	SUPERFAMILY
SSF75445			SUPERFAMILY
PTHR11934		Ribose5P_isomerase_type_A	PANTHER
NF001924	rpiA		NCBIFAM
TIGR00021	rpiA	Ribose5P_isomerase_type_A	NCBIFAM

Orthologs

RPIA (HGNC:10297) Homo sapiens
rki1 (SJAG_00070) Schizosaccharomyces japonicus
RKI1 (YOR095C) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.: Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.: Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.: Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:9872416 - Repression of enzymes of the pentose phosphate pathway by glucose in fission yeast.: Mehta S et al. FEBS Lett 1998 Dec 04;440(3):430-3