protein coding gene - cia2 (SPAC144.16) - CIA machinery protein Cia2

Gene summary

Standard name: cia2
Systematic ID: SPAC144.16
Product: CIA machinery protein Cia2
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UTL0
ORFeome ID: 05/05E03
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 4686490..4688886 forward strand

Annotation

GO biological process

GO:0051604 - protein maturation

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0097361 - cytosolic [4Fe-4S] assembly targeting complex

References:

PMID:34660592

GO:0005634 - nucleus

References:

PMID:16823372

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

PomGeneEx:0000011 - RNA level increased

References:

PMID:27984744

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:24763107

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

cia2delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

cia2delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01883	FeS_assembly_P	MIP18-like	PFAM
G3DSA:3.30.300.130:FF:000004			FUNFAM
SSF117916	Fe-S cluster assembly (FSCA) domain-like	FSCA_dom_sf	SUPERFAMILY
G3DSA:6.10.250.1280			GENE3D
G3DSA:3.30.300.130		FSCA_dom_sf	GENE3D
PTHR12377	CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED	MIP18	PANTHER
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder

Orthologs

CIAO2B (HGNC:24261) Homo sapiens
cia2 (SJAG_00040) Schizosaccharomyces japonicus
CIA2 (YHR122W) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34660592 - Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism.: Shi R et al. Front Cell Dev Biol 2021;9:735678
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7