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protein coding gene - npt1 (SPAC1486.06) - nicotinate phosphoribosyltransferase Npt1

Gene summary

Standard name
npt1
Systematic ID
SPAC1486.06
Product
nicotinate phosphoribosyltransferase Npt1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTK3
ORFeome ID
19/19F05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 3203849..3205821 forward strand

Annotation

GO biological process

GO:0034355 - NAD+ biosynthetic process via the salvage pathway

References:

GO:0019358 - nicotinate nucleotide salvage

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004516 - nicotinate phosphoribosyltransferase activity

References:

Modification

MOD:00890 - phosphorylated L-histidine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04095NAPRTaseN/Namide_PRibTrfasePfam
PF17767NAPRTase_NNAPRTase_NPfam
cd01401PncB_likeNic_PRibTrfaseCDD
G3DSA:3.20.140.10:FF:000009CATH-FunFam
G3DSA:3.20.140.10CATH-Gene3D
SSF51690Nicotinate_pribotase-like_CSUPERFAMILY
SSF54675SUPERFAMILY
PTHR11098Nic_PRibTrfase-FamPANTHER
PIRSF000484NAPRTNic_PRibTrfase-FamPIRSF
NF003704PRK05321.1Nic_PRibTrfaseNCBIFAM
TIGR01514NAPRTaseNic_PRibTrfaseNCBIFAM
MF_00570NAPRTaseNic_PRibTrfaseHAMAP

Orthologs

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36