protein coding gene - npt1 (SPAC1486.06) - nicotinate phosphoribosyltransferase Npt1

Gene summary

Standard name: npt1
Systematic ID: SPAC1486.06
Product: nicotinate phosphoribosyltransferase Npt1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UTK3
ORFeome ID: 19/19F05
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 3203849..3205821 forward strand

Annotation

GO biological process

GO:0034355 - NAD+ biosynthetic process via the salvage pathway

References:

GO_REF:0000033

GO:0019358 - nicotinate nucleotide salvage

References:

GO_REF:0000024

GO cellular component

GO:0005829 - cytosol

References:

GO_REF:0000033

GO:0005739 - mitochondrion

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0004516 - nicotinate phosphoribosyltransferase activity

References:

GO_REF:0000033

Modification

MOD:00890 - phosphorylated L-histidine

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

npt1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

npt1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF17767	NAPRTase_N	NAPRTase_N	PFAM
PF04095	NAPRTase	N/Namide_PRibTrfase	PFAM
cd01401	PncB_like	Nic_PRibTrfase	CDD
G3DSA:3.20.140.10:FF:000009			FUNFAM
SSF54675	Nicotinate/Quinolinate PRTase N-terminal domain-like		SUPERFAMILY
SSF51690	Nicotinate/Quinolinate PRTase C-terminal domain-like	Nicotinate_pribotase-like_C	SUPERFAMILY
G3DSA:3.20.140.10	nicotinate phosphoribosyltransferase		GENE3D
PTHR11098	NICOTINATE PHOSPHORIBOSYLTRANSFERASE	Nic_PRibTrfase-Fam	PANTHER
PIRSF000484	NAPRT	Nic_PRibTrfase-Fam	PIRSF
MF_00570	NAPRTase	Nic_PRibTrfase	HAMAP
NF003704	PRK05321.1	Nic_PRibTrfase	NCBIFAM
TIGR01514	NAPRTase	Nic_PRibTrfase	NCBIFAM

Orthologs

NAPRT (HGNC:30450) Homo sapiens
npt1 (SJAG_03298) Schizosaccharomyces japonicus
NPT1 (YOR209C) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6