protein coding gene - nob1 (SPAC1486.09) - ribosome biogenesis protein Nob1

Gene summary

Standard name: nob1
Systematic ID: SPAC1486.09
Product: ribosome biogenesis protein Nob1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UTK0
ORFeome ID: 44/44D04
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 3209887..3211529 forward strand

Annotation

GO biological process

GO:0030490 - maturation of SSU-rRNA

References:

GO_REF:0000033

GO cellular component

GO:0005737 - cytoplasm

References:

GO_REF:0000117

GO:0031981 - nuclear lumen

References:

GO_REF:0000117

GO:0005634 - nucleus

References:

PMID:16823372

GO:0030688 - preribosome, small subunit precursor

References:

GO_REF:0000033

GO molecular function

GO:0003723 - RNA binding

References:

GO_REF:0000024

GO:0004521 - RNA endonuclease activity

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Protein features

PBO:0111881 - PINc domain

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

nob1delta

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

PMID:23697806

Genotypes:

nob1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

nob1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF08772	Zn_ribbon_NOB1	NOB1_Zn-bd	Pfam
PF17146	PIN_6	Ribonuclease_PIN	Pfam
cd09876	PIN_Nob1-like	Ribonuclease_PIN	CDD
SM00670	PINc	PIN_dom	SMART
G3DSA:3.40.50.1010:FF:000020			CATH-FunFam
G3DSA:3.40.50.1010			CATH-Gene3D
G3DSA:6.20.210.10		NOB1_Zf-like_sf	CATH-Gene3D
SSF144206		NOB1_Zf-like_sf	SUPERFAMILY
PTHR12814		NOB1	PANTHER
PIRSF037125	D-site_20S_pre-rRNA_nuclease	Nob1_euk	PIRSF
mobidb-lite-Disorder	disorder_prediction		MobiDB-Disorder
mobidb-lite-Negative-Polyelectrolyte	disorder_prediction		MobiDB-Negative-Polyelectrolyte
mobidb-lite-Polar	disorder_prediction		MobiDB-Polar
mobidb-lite-Polyampholyte	disorder_prediction		MobiDB-Polyampholyte

Orthologs

NOB1 (HGNC:29540) Homo sapiens
nob1 (SJAG_03539) Schizosaccharomyces japonicus
NOB1 (YOR056C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.: Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.: Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.: Zhang K et al. Science 2011 Mar 25;331(6024):1624-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105