protein coding gene - mek1 (SPAC14C4.03) - Cds1/Rad53/Chk2 family protein kinase Mek1

Gene summary

Standard name

mek1

Systematic ID

SPAC14C4.03

Product

Cds1/Rad53/Chk2 family protein kinase Mek1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q10292

ORFeome ID

44/44F05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 5231140..5232566 forward strand

Annotation

Protein features

Orthologs

• mek1 (SJAG_03438) Schizosaccharomyces japonicus
• MEK1 (YOR351C) Saccharomyces cerevisiae

References / Literature

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:20622014 - Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.

St-André O et al. J Biol Chem 2010 Sep 03;285(36):27859-68

PMID:20123974 - Roles of Hop1 and Mek1 in meiotic chromosome pairing and recombination partner choice in Schizosaccharomyces pombe.

Latypov V et al. Mol Cell Biol 2010 Apr;30(7):1570-81

PMID:21084840 - The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.

Tougan T et al. Cell Cycle 2010 Dec 01;9(23):4688-702

PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

GO_REF:0000002 - Comments

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842

PMID:23151475 - RNAi triggered by specialized machinery silences developmental genes and retrotransposons.

Yamanaka S et al. Nature 2013 Jan 24;493(7433):557-60

PMID:12482912 - Regulation of meiotic progression by the meiosis-specific checkpoint kinase Mek1 in fission yeast.

Pérez-Hidalgo L et al. J Cell Sci 2003 Jan 15;116(Pt 2):259-71

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:28986445 - Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo .

Kniewel R et al. Genetics 2017 Dec;207(4):1313-1333

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:15226405 - S. pombe meiotic linear elements contain proteins related to synaptonemal complex components.

Lorenz A et al. J Cell Sci 2004 Jul 01;117(Pt 15):3343-51

PMID:12032093 - The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast.

Shimada M et al. EMBO J 2002 Jun 03;21(11):2807-18

PMID:30289413 - Structural insights into the recognition of phosphorylated Hop1 by Mek1.

Xie C et al. Acta Crystallogr D Struct Biol 2018 Oct 01;74(Pt 10):1027-1038

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:8943016 - The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.

Gilbreth M et al. Proc Natl Acad Sci U S A 1996 Nov 26;93(24):13802-7

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:19911044 - Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast.

Rothenberg M et al. PLoS Genet 2009 Nov;5(11):e1000722

PMID:16532353 - Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe.

Lorenz A et al. Chromosoma 2006 Aug;115(4):330-40

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83