protein coding gene - rad17 (SPAC14C4.13) - RFC related checkpoint protein Rad17

Gene summary

Standard name

rad17

Systematic ID

SPAC14C4.13

Product

RFC related checkpoint protein Rad17

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P50531

ORFeome ID

26/26G07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 5253313..5255892 forward strand

Annotation

Protein features

Orthologs

• RAD17 (HGNC:9807) Homo sapiens
• rad17 (SJAG_02563) Schizosaccharomyces japonicus
• RAD24 (YER173W) Saccharomyces cerevisiae

References / Literature

PMID:21945095 - Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1).

Taylor M et al. DNA Repair (Amst) 2011 Nov 10;10(11):1154-63

PMID:166019 - Genetic control of radiation sensitivity in Schizosaccharomyces pombe.

Nasim A et al. Genetics 1975 Apr;79(4):573-82

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:12839619 - High dosage Rhp51 suppression of the MMS sensitivity of DNA structure checkpoint mutants reveals a relationship between Crb2 and Rhp51.

Smeets MF et al. Genes Cells 2003 Jul;8(7):573-86

PMID:12871901 - The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication.

Yoshida SH et al. Genetics 2003 Jul;164(3):881-93

PMID:12186947 - A novel chk1-dependent G1/M checkpoint in fission yeast.

Synnes M et al. J Cell Sci 2002 Sep 15;115(Pt 18):3609-18

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:16371652 - Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast.

Marchetti MA et al. J Cell Sci 2006 Jan 01;119(Pt 1):124-31

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:10757807 - Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated.

Wang SW et al. Mol Cell Biol 2000 May;20(9):3234-44

PMID:12865439 - Delineating the position of rad4+/cut5+ within the DNA-structure checkpoint pathways in Schizosaccharomyces pombe.

Harris S et al. J Cell Sci 2003 Sep 01;116(Pt 17):3519-29

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:11226171 - Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.

Manolis KG et al. EMBO J 2001 Jan 15;20(1-2):210-21

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:15210864 - Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates with Meu13 and is required for meiotic recombination.

Saito TT et al. Nucleic Acids Res 2004;32(11):3325-39

PMID:28441348 - Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication.

Fleck O et al. Genes (Basel) 2017 Apr 25;8(5)

PMID:9092625 - Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.

Shayeghi M et al. Nucleic Acids Res 1997 Mar 15;25(6):1162-9

PMID:9658208 - Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants.

Perego P et al. Mol Pharmacol 1998 Jul;54(1):213-9

PMID:19205745 - Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.

Yasuhira S Mol Genet Genomics 2009 May;281(5):497-509

PMID:9693370 - Mutational effect of fission yeast polalpha on cell cycle events.

Bhaumik D et al. Mol Biol Cell 1998 Aug;9(8):2107-23

PMID:10954610 - The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.

Kim M et al. Nucleic Acids Res 2000 Sep 01;28(17):3392-402

PMID:10559981 - A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins.

Edwards RJ et al. Nat Cell Biol 1999 Nov;1(7):393-8

PMID:22797921 - Heat induction of a novel Rad9 variant from a cryptic translation initiation site reduces mitotic commitment.

Janes S et al. J Cell Sci 2012 Oct 01;125(Pt 19):4487-97

PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62

PMID:12032307 - A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway.

Marchetti MA et al. Proc Natl Acad Sci U S A 2002 May 28;99(11):7472-7

PMID:11073995 - Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51(+) from Schizosaccharomyces pombe.

Shim YS et al. Mol Cell Biol 2000 Dec;20(23):8958-68

PMID:15498101 - Germinating fission yeast spores delay in G1 in response to UV irradiation.

Nilssen EA et al. BMC Cell Biol 2004 Oct 21;5(1):40

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:9739083 - Cdc18p can block mitosis by two independent mechanisms.

Greenwood E et al. J Cell Sci 1998 Oct;111 ( Pt 20):3101-8

PMID:12514100 - Checkpoint activation regulates mutagenic translesion synthesis.

Kai M et al. Genes Dev 2003 Jan 01;17(1):64-76

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:8834792 - Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity.

Muris DF et al. J Cell Sci 1996 Jan;109 ( Pt 1):73-81

PMID:12589755 - The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway.

Kanoh J et al. J Mol Biol 2003 Feb 28;326(4):1081-94

PMID:26368543 - Critical Function of γH2A in S-Phase.

Mejia-Ramirez E et al. PLoS Genet 2015 Sep;11(9):e1005517

PMID:31332096 - A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3 ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.

Xu YJ et al. Mol Cell Biol 2019 Oct 15;39(20)

PMID:9524127 - Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage.

Kostrub CF et al. EMBO J 1998 Apr 01;17(7):2055-66

PMID:11027257 - Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation.

Tan S et al. Mol Cell Biol 2000 Nov;20(21):7853-66

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52

PMID:20505337 - Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.

Khair L et al. Cell Cycle 2010 Jun 01;9(11):2237-48

PMID:12062100 - Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Saitoh S et al. Cell 2002 May 31;109(5):563-73

PMID:19546237 - TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.

Schonbrun M et al. Mol Cell Biol 2009 Aug;29(16):4584-94

PMID:11313455 - Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures.

Kai M et al. Mol Cell Biol 2001 May;21(10):3289-301

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:18045993 - RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.

Ansbach AB et al. Mol Biol Cell 2008 Feb;19(2):595-607

PMID:12930957 - Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.

Meister P et al. Nucleic Acids Res 2003 Sep 01;31(17):5064-73

PMID:21493688 - Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.

Guarino E et al. Nucleic Acids Res 2011 Aug;39(14):5978-90

PMID:17690116 - Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.

Fersht N et al. Nucleic Acids Res 2007;35(16):5323-37

PMID:1563349 - Checkpoint controls in Schizosaccharomyces pombe: rad1.

Rowley R et al. EMBO J 1992 Apr;11(4):1335-42

PMID:8019001 - Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.

al-Khodairy F et al. Mol Biol Cell 1994 Feb;5(2):147-60

PMID:9487130 - Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.

Dahlen M et al. Mol Biol Cell 1998 Mar;9(3):611-21

PMID:10648611 - Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9.

Caspari T et al. Mol Cell Biol 2000 Feb;20(4):1254-62

PMID:10208430 - hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.

Li L et al. Oncogene 1999 Mar 04;18(9):1689-99

PMID:1427071 - Fission yeast genes involved in coupling mitosis to completion of DNA replication.

Enoch T et al. Genes Dev 1992 Nov;6(11):2035-46

PMID:16723501 - Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.

Taricani L et al. Mol Biol Cell 2006 Aug;17(8):3456-68

PMID:22645654 - Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Akai Y et al. Open Biol 2011 Dec;1(4):110023

PMID:10588638 - Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints.

Shimada M et al. Mol Biol Cell 1999 Dec;10(12):3991-4003

PMID:18378696 - Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

Akamatsu Y et al. Mol Cell Biol 2008 Jun;28(11):3639-51

PMID:24806966 - The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.

Tsang E et al. J Cell Sci 2014 Jul 01;127(Pt 13):2983-94

PMID:12032093 - The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast.

Shimada M et al. EMBO J 2002 Jun 03;21(11):2807-18

PMID:16816416 - Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1.

Calonge TM et al. Genetics 2006 Sep;174(1):113-23

PMID:18667534 - Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.

Yin L et al. Mol Biol Cell 2008 Oct;19(10):4374-82

PMID:10521402 - Meiotic DNA replication checkpoint control in fission yeast.

Murakami H et al. Genes Dev 1999 Oct 01;13(19):2581-93

PMID:10683155 - A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.

Griffiths D et al. J Cell Sci 2000 Mar;113 ( Pt 6):1075-88

PMID:21095590 - DDK phosphorylates checkpoint clamp component Rad9 and promotes its release from damaged chromatin.

Furuya K et al. Mol Cell 2010 Nov 24;40(4):606-18

PMID:21561865 - The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.

Yue M et al. J Biol Chem 2011 Jul 01;286(26):22864-74

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:22792081 - Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.

Qu M et al. PLoS Genet 2012 Jul;8(7):e1002817

PMID:11809834 - Fission yeast F-box protein Pof3 is required for genome integrity and telomere function.

Katayama S et al. Mol Biol Cell 2002 Jan;13(1):211-24

PMID:18675827 - The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+).

Jansson K et al. Mutat Res 2008 Sep 26;644(1-2):48-55

PMID:11884512 - Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease.

Taylor DL et al. J Cell Sci 2002 Mar 15;115(Pt 6):1113-22

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:15972456 - Brc1-mediated DNA repair and damage tolerance.

Sheedy DM et al. Genetics 2005 Oct;171(2):457-68

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:7254221 - Spontaneous and UV-induced recombination in radiation-sensitive mutants of Schizosaccharomyces pombe.

Grossenbacher-Grunder AM et al. Mutat Res 1981 Mar;81(1):37-48

PMID:8846774 - Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.

Griffiths DJ et al. EMBO J 1995 Dec 01;14(23):5812-23

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:9563836 - Mutant PCNA alleles are associated with cdc phenotypes and sensitivity to DNA damage in fission yeast.

Arroyo MP et al. Mol Gen Genet 1998 Mar;257(5):505-18

PMID:20176980 - Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.

Dolan WP et al. Genetics 2010 May;185(1):39-53

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:15340008 - Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.

Win TZ et al. J Cell Sci 2004 Sep 15;117(Pt 20):4769-78