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protein coding gene - atp1 (SPAC14C4.14) - F1-FO ATP synthase alpha subunit

Gene summary

Standard name
atp1
Systematic ID
SPAC14C4.14
Product
F1-FO ATP synthase alpha subunit
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P24487
ORFeome ID
37/37C03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5256726..5261958 forward strand

Annotation

Disease association

MONDO:0020727 - combined oxidative phosphorylation deficiency 22

References:

MONDO:0957254 - mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A

References:

MONDO:0014091 - mitochondrial complex V (ATP synthase) deficiency, nuclear type 4B

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GO biological process

GO:0042776 - proton motive force-driven mitochondrial ATP synthesis

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GO:1902600 - proton transmembrane transport

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GO cellular component

GO:0099617 - matrix side of mitochondrial inner membrane

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GO:0045259 - proton-transporting ATP synthase complex

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GO molecular function

GO:0043531 - ADP binding

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GO:0005524 - ATP binding

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GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0001934 - abolished cell population growth on glycerol carbon source

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Genotypes:

FYPO:0003690 - abolished cell population growth on glycerol/ethanol carbon source

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0000442 - decreased cell population growth on glycerol/ethanol carbon source

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Genotypes:

FYPO:0001938 - decreased cytochrome-c oxidase activity

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0002056 - decreased mitochondrial translation

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Genotypes:

FYPO:0001936 - decreased proton-transporting ATP synthase activity, rotational mechanism

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Genotypes:

FYPO:0001940 - decreased ubiquinol-cytochrome-c reductase activity

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Genotypes:

FYPO:0000035 - growth auxotrophic for arginine

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0001984 - protein absent from cell during vegetative growth

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000093 - sensitive to arsenic

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Genotypes:

FYPO:0001245 - sensitive to cobalt

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00006ATP-synt_abATPase_F1/V1/A1_a/bsu_nucl-bdPfam
PF00306ATP-synt_ab_CATP_synth_asu_CPfam
PF02874ATP-synt_ab_NATPase_F1/V1/A1_a/bsu_NPfam
cd01132F1-ATPase_alpha_CDATP_synth_F1_a_nt-bd_domCDD
cd18113ATP-synt_F1_alpha_CATP_synth_asu_CCDD
cd18116ATP-synt_F1_alpha_NCDD
PS00152ATPASE_ALPHA_BETAATPase_a/bsu_ASPROSITE patterns
G3DSA:1.20.150.20:FF:000001CATH-FunFam
G3DSA:2.40.30.20:FF:000001CATH-FunFam
G3DSA:3.40.50.300:FF:004039CATH-FunFam
G3DSA:1.20.150.20ATP_synth_asu_C_sfCATH-Gene3D
G3DSA:2.40.30.20ATP_synth_asu-like_sfCATH-Gene3D
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF47917SUPERFAMILY
SSF50615ATPase_F1/V1/A1_a/bsu_N_sfSUPERFAMILY
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR48082ATP_synth_F1_asuPANTHER
PIRSF039088F_ATPase_subunit_alphaATP_synth_F1_asuPIRSF
NF009884PRK13343.1NCBIFAM
TIGR00962atpAATP_synth_F1_asuNCBIFAM
MF_01346ATP_synth_alpha_bactATP_synth_F1_asuHAMAP

Orthologs

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.
Calvo IA et al. iScience 2021 Nov 19;24(11):103338
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:14701807 - The molecular chaperone, Atp12p, from Homo sapiens. In vitro studies with purified wild type and mutant (E240K) proteins.
Hinton A et al. J Biol Chem 2004 Mar 05;279(10):9016-22
PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .
Wiley DJ et al. Front Physiol 2020;11:427
PMID:38360270 - A KDELR-mediated ER-retrieval system modulates mitochondrial functions via the unfolded protein response in fission yeast.
Zhu M et al. J Biol Chem 2024 Feb 13;:105754
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:15282184 - Structural insight into the cooperativity between catalytic and noncatalytic sites of F1-ATPase.
Falson P et al. Biochim Biophys Acta 2004 Jul 23;1658(1-2):133-40
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.
Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62
PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
PMID:27664110 - Loss of Msp1p in Schizosaccharomyces pombe induces a ROS-dependent nuclear mutator phenotype that affects mitochondrial fission genes.
Delerue T et al. FEBS Lett 2016 Oct;590(20):3544-3558
PMID:36799444 - Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.
Hirano Y et al. J Biochem 2023 Jun 30;174(1):33-46
PMID:6214396 - Alterations of the alpha or beta subunits of the mitochondrial ATPase in yeast mutants.
Boutry M et al. Eur J Biochem 1982 Jul;125(3):471-7
PMID:1824697 - Alpha subunit of mitochondrial F1-ATPase from the fission yeast. Deduced sequence of the wild type and identification of a mutation that alters apparent negative cooperativity.
Falson P et al. J Biol Chem 1991 Jan 05;266(1):287-93
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20621843 - Processing of the dynamin Msp1p in S. pombe reveals an evolutionary switch between its orthologs Mgm1p in S. cerevisiae and OPA1 in mammals.
Leroy I et al. FEBS Lett 2010 Jul 16;584(14):3153-7
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.
Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000051 - S. pombe keyword mapping
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:32896087 - Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast.
Malecki M et al. EMBO Rep 2020 Nov 05;21(11):e50845