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protein coding gene - mok11 (SPAC1527.01) - cell wall alpha-1,3-glucan synthase Mok11

Gene summary

Standard name
mok11
Systematic ID
SPAC1527.01
Product
cell wall alpha-1,3-glucan synthase Mok11
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC23D3.15
UniProt ID
Q09854
ORFeome ID
34/34B10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4374363..4382775 forward strand

Annotation

GO biological process

GO:0070600 - fungal-type cell wall (1->3)-alpha-glucan biosynthetic process

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GO cellular component

GO:0005886 - plasma membrane

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GO molecular function

GO:0047657 - alpha-1,3-glucan synthase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0002161 - normal growth on Calcofluor White

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Genotypes:

FYPO:0004892 - normal growth on echinocandin

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Genotypes:

FYPO:0001315 - normal vegetative cell morphology

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000015 - RNA absent

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

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Genotypes:

FYPO:0003797 - normal conjugation frequency

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Genotypes:

FYPO:0002161 - normal growth on Calcofluor White

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Genotypes:

FYPO:0004892 - normal growth on echinocandin

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Genotypes:

FYPO:0000590 - normal sporulation

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Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF2612712TM_Mok13Mok11-14/Ags1-like_TMPFAM
PF26111Ig_Mok13Mok11-13/Ags1-like_IgPFAM
PF26108GH_Mok13Mok11-13/Ags1-like_GHPFAM
PF26114Ig_2_Mok13Mok11-13/Ags1-like_Ig_2PFAM
PF26775HTH_Mok13HTH_Mok13PFAM
PF00128Alpha-amylaseGH13_cat_domPFAM
PF08323Glyco_transf_5Starch_synth_cat_domPFAM
PF00534Glycos_transf_1Glyco_trans_1PFAM
PF26122CBM_Mok13Mok11-13/Ags1-like_CBMPFAM
cd11323AmyAc_AGSCDD
cd06174MFSCDD
SM00642aamyGH13_cat_domSMART
G3DSA:3.20.20.80:FF:000073FUNFAM
G3DSA:3.40.50.2000:FF:000052FUNFAM
SSF51445(Trans)glycosidasesGH_hydrolase_sfSUPERFAMILY
SSF53756UDP-Glycosyltransferase/glycogen phosphorylaseSUPERFAMILY
G3DSA:3.20.20.80GlycosidasesGENE3D
G3DSA:3.40.50.2000Glycogen Phosphorylase B;GENE3D
PTHR47182CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATEDMok11-14/Ags1-likePANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity

Orthologs

References / Literature

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
GO_REF:0000051 - S. pombe keyword mapping
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:16420355 - Synthesis of alpha-glucans in fission yeast spores is carried out by three alpha-glucan synthase paralogues, Mok12p, Mok13p and Mok14p.
García I et al. Mol Microbiol 2006 Feb;59(3):836-53
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:10087262 - Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.
Katayama S et al. J Cell Biol 1999 Mar 22;144(6):1173-86
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000002 - Comments
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105