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protein coding gene - rad50 (SPAC1556.01c) - DNA repair protein Rad50

Gene summary

Standard name
rad50
Systematic ID
SPAC1556.01c
Product
DNA repair protein Rad50
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAP4C9.01c
UniProt ID
Q9UTJ8
ORFeome ID
39/39D10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3791753..3795998 reverse strand

Annotation

Disease association

MONDO:0013118 - Nijmegen breakage syndrome-like disorder

References:

GO biological process

GO:0000729 - DNA double-strand break processing

References:

GO:1990918 - double-strand break repair involved in meiotic recombination

References:

GO:0000724 - double-strand break repair via homologous recombination

References:

GO:0006303 - double-strand break repair via nonhomologous end joining

References:

GO:0007534 - gene conversion at mating-type locus

References:

GO:0042138 - meiotic DNA double-strand break formation

References:

GO:0031573 - mitotic intra-S DNA damage checkpoint signaling

References:

GO:1990426 - mitotic recombination-dependent replication fork processing

References:

GO:0010520 - regulation of reciprocal meiotic recombination

References:

GO:0031297 - replication fork processing

References:

GO:0120290 - stalled replication fork localization to nuclear periphery

References:

GO:0000723 - telomere maintenance

References:

GO:0000722 - telomere maintenance via recombination

References:

GO:0007004 - telomere maintenance via telomerase

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0000794 - condensed nuclear chromosome

References:

GO:0030870 - Mre11 complex

References:

GO:0035861 - site of double-strand break

References:

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0045027 - DNA end binding

References:

GO:0003678 - DNA helicase activity

References:

GO:0003691 - double-stranded telomeric DNA binding

References:

GO:0051880 - G-quadruplex DNA binding

References:

GO:0043047 - single-stranded telomeric DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Multi-locus phenotype

FYPO:0006087 - abolished DNA resection during replication fork processing

References:

Genotypes:

FYPO:0002472 - abolished histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002597 - abolished histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0002702 - circularized chromosome

References:

Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

References:

Genotypes:

FYPO:0003411 - decreased chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0004867 - decreased histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0005433 - decreased meiotic recombination at hotspot

References:

Genotypes:

FYPO:0005388 - decreased number of Rad51 foci during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0007532 - decreased replication fork colocalization with nuclear pore complex

References:

Genotypes:

FYPO:0003589 - decreased replication slippage during replication fork processing

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0005434 - globally decreased meiotic recombination

References:

Genotypes:

FYPO:0005406 - increased DNA recombination at telomere following meiotic cell cycle

References:

Genotypes:

FYPO:0002596 - increased histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0004656 - increased protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0005402 - increased telomeric 3' overhang length during vegetative growth

References:

Genotypes:

FYPO:0000316 - inviable after spore germination

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006323 - loss of viability following replication fork stalling

References:

Genotypes:

FYPO:0006319 - normal extent of DNA resection during replication fork processing

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0007149 - normal growth on N-methyl-N'-nitro-N-nitrosoguanidine

References:

Genotypes:

FYPO:0005936 - normal intragenic meiotic recombination frequency

References:

Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0006320 - normal replication slippage during replication fork processing

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0005549 - normal viability upon nitrogen starvation

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0003858 - sensitive to etoposide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0005919 - sensitive to TOP-53

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0005403 - telomeric 3' overhang absent during vegetative growth

References:

Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

Protein features

PBO:0111792 - AAA family ATPase

PBO:0111821 - SMC family

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001352 - abnormal chromatin organization during vegetative growth

References:

Genotypes:

FYPO:0005913 - abnormal chromatin remodeling during meiosis I

References:

Genotypes:

FYPO:0000427 - abnormal G1 to G0 transition

References:

Genotypes:

FYPO:0003564 - abnormal meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

References:

Genotypes:

FYPO:0005268 - abnormal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0003088 - abnormal replication fork arrest

References:

Genotypes:

FYPO:0002254 - abnormal telomere morphology during vegetative growth

References:

Genotypes:

FYPO:0005453 - abolished break-induced loss of heterozygosity via chromosomal translocation

References:

Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0000484 - abolished meiotic recombination

References:

Genotypes:

FYPO:0005140 - abolished meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0003486 - abolished protein localization to double-strand break site

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0005451 - decreased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0006677 - decreased DNA binding at double-strand break

References:

Genotypes:

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0004867 - decreased histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0005433 - decreased meiotic recombination at hotspot

References:

Genotypes:

FYPO:0005141 - decreased meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0005431 - decreased mitotic recombination at hotspot

References:

Genotypes:

FYPO:0005388 - decreased number of Rad51 foci during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0003589 - decreased replication slippage during replication fork processing

References:

Genotypes:

FYPO:0005375 - decreased sister chromatid meiotic recombination

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0005911 - delayed onset of meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0005914 - elongated linear element

References:

Genotypes:

FYPO:0009077 - increased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009052 - increased cell population growth on glutamate nitrogen source

References:

Genotypes:

FYPO:0009101 - increased cell population growth on glycerol and galactose carbon source

References:

Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009093 - increased cell population growth on lysine and serine nitrogen source

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0009028 - increased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0009074 - increased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0009096 - increased cell population growth on xylose carbon source

References:

Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0000657 - increased DNA binding

References:

Genotypes:

FYPO:0004260 - increased duration of protein localization to double-strand break site

References:

Genotypes:

FYPO:0001386 - increased haploidization

References:

Genotypes:

FYPO:0002484 - increased intergenic meiotic recombination

References:

Genotypes:

FYPO:0004057 - increased intragenic meiotic recombination

References:

Genotypes:

FYPO:0000487 - increased meiotic recombination

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0006322 - increased protein localization to chromatin at stalled replication fork

References:

Genotypes:

FYPO:0002475 - increased protein localization to double-strand break site

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0004665 - linear elements absent from cell

References:

Genotypes:

FYPO:0006323 - loss of viability following replication fork stalling

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0001929 - normal cell cycle regulation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001927 - normal cell cycle regulation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0004286 - normal double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0003082 - normal genetic imprinting at mating-type locus

References:

Genotypes:

FYPO:0004229 - normal growth during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0005942 - normal intergenic meiotic recombination frequency

References:

Genotypes:

FYPO:0005936 - normal intragenic meiotic recombination frequency

References:

Genotypes:

FYPO:0005912 - normal meiosis-specific chromatin remodeling

References:

Genotypes:

FYPO:0005136 - normal meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0000488 - normal meiotic recombination

References:

Genotypes:

FYPO:0004059 - normal meiotic recombination at CRE promoter

References:

Genotypes:

FYPO:0005138 - normal meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0005373 - normal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0002554 - normal protein localization to double-strand break site

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0009032 - resistance to bortezomib

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

References:

Genotypes:

FYPO:0002634 - resistance to cobalt

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

References:

Genotypes:

FYPO:0009039 - resistance to potassium chloride

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0005266 - resistance to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009040 - resistance to tea tree oil

References:

Genotypes:

FYPO:0002767 - resistance to terbinafine

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001188 - sensitive to Calcofluor White

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0003858 - sensitive to etoposide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009084 - sensitive to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001813 - sensitive to N-methyl-N'-nitro-N-nitrosoguanidine

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

References:

Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0005919 - sensitive to TOP-53

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0009064 - sensitive to X-rays and rapamycin during vegetative growth.

References:

Genotypes:

FYPO:0009063 - sensitive to X-rays during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0005455 - telomere assembly at double-strand break site

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF13476AAA_23Rad50/SbcC_AAAPFAM
PS51131ZN_HOOKZn_hook_RAD50PROSITE_PROFILES
G3DSA:3.40.50.300:FF:000593FUNFAM
G3DSA:3.40.50.300:FF:001195FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR18867RAD50PANTHER
CoilCoilCOILS
TIGR00606rad50Rad50_eukaryotesNCBIFAM

Orthologs

References / Literature

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:28475874 - Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.
Ait Saada A et al. Mol Cell 2017 May 04;66(3):398-410.e4
PMID:18854158 - Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Williams RS et al. Cell 2008 Oct 03;135(1):97-109
PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52
PMID:12023299 - Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III.
Caspari T et al. Genes Dev 2002 May 15;16(10):1195-208
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:19911044 - Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast.
Rothenberg M et al. PLoS Genet 2009 Nov;5(11):e1000722
PMID:24493214 - ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Deshpande RA et al. EMBO J 2014 Mar 03;33(5):482-500
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:24089141 - DNA intermediates of meiotic recombination in synchronous S. pombe at optimal temperature.
Hyppa RW et al. Nucleic Acids Res 2014 Jan;42(1):359-69
PMID:17936710 - Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.
Limbo O et al. Mol Cell 2007 Oct 12;28(1):134-46
PMID:18344406 - Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.
Haldar D et al. Eukaryot Cell 2008 May;7(5):800-13
PMID:20123974 - Roles of Hop1 and Mek1 in meiotic chromosome pairing and recombination partner choice in Schizosaccharomyces pombe.
Latypov V et al. Mol Cell Biol 2010 Apr;30(7):1570-81
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:24806966 - The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.
Tsang E et al. J Cell Sci 2014 Jul 01;127(Pt 13):2983-94
PMID:14654689 - A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.
Ono Y et al. Nucleic Acids Res 2003 Dec 15;31(24):7141-9
PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.
Gómez EB et al. Genetics 2008 Jun;179(2):757-71
PMID:19752195 - Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.
Milman N et al. Mol Cell Biol 2009 Nov;29(22):5998-6005
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23093942 - Recovery of arrested replication forks by homologous recombination is error-prone.
Iraqui I et al. PLoS Genet 2012;8(10):e1002976
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:28292918 - Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe .
Li Y et al. Genetics 2017 May;206(1):481-496
PMID:18160711 - Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.
Subramanian L et al. Mol Cell Biol 2008 Mar;28(5):1443-55
PMID:15485922 - Fission yeast Dna2 is required for generation of the telomeric single-strand overhang.
Tomita K et al. Mol Cell Biol 2004 Nov;24(21):9557-67
PMID:17724078 - Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.
Cullen JK et al. Mol Cell Biol 2007 Nov;27(21):7745-57
PMID:12944481 - Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.
Ueno M et al. Mol Cell Biol 2003 Sep;23(18):6553-63
PMID:17209013 - Role of SUMO in the dynamics of telomere maintenance in fission yeast.
Xhemalce B et al. Proc Natl Acad Sci U S A 2007 Jan 16;104(3):893-8
PMID:33836577 - A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
Zdravković A et al. Proc Natl Acad Sci U S A 2021 Mar 16;118(11)
PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.
Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:18615848 - Role of heterochromatin in suppressing subtelomeric recombination in fission yeast.
Bisht KK et al. Yeast 2008 Aug;25(8):537-48
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43
PMID:27473316 - Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.
Ranatunga NS et al. G3 (Bethesda) 2016 Oct 13;6(10):3049-3063
PMID:29622660 - RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.
Zhao H et al. EMBO Rep 2018 May;19(5)
PMID:29215009 - The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.
Teixeira-Silva A et al. Nat Commun 2017 Dec 07;8(1):1982
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23080121 - Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Limbo O et al. Nucleic Acids Res 2012 Dec;40(22):11435-49
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26518661 - The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.
Sadeghi L et al. EMBO Rep 2015 Dec;16(12):1673-87
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