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protein coding gene - rad50 (SPAC1556.01c) - DNA repair protein Rad50

Gene summary

Standard name
rad50
Systematic ID
SPAC1556.01c
Product
DNA repair protein Rad50
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAP4C9.01c
UniProt ID
Q9UTJ8
ORFeome ID
39/39D10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3791753..3795998 reverse strand

Annotation

Disease association

MONDO:0013118 - Nijmegen breakage syndrome-like disorder

References:

GO biological process

GO:0000729 - DNA double-strand break processing

References:

GO:1990918 - double-strand break repair involved in meiotic recombination

References:

GO:0000724 - double-strand break repair via homologous recombination

References:

GO:0006303 - double-strand break repair via nonhomologous end joining

References:

GO:0007534 - gene conversion at mating-type locus

References:

GO:0042138 - meiotic DNA double-strand break formation

References:

GO:0031573 - mitotic intra-S DNA damage checkpoint signaling

References:

GO:1990426 - mitotic recombination-dependent replication fork processing

References:

GO:0010520 - regulation of reciprocal meiotic recombination

References:

GO:0031297 - replication fork processing

References:

GO:0120290 - stalled replication fork localization to nuclear periphery

References:

GO:0000723 - telomere maintenance

References:

GO:0000722 - telomere maintenance via recombination

References:

GO:0007004 - telomere maintenance via telomerase

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0000794 - condensed nuclear chromosome

References:

GO:0030870 - Mre11 complex

References:

GO:0005634 - nucleus

References:

GO:0035861 - site of double-strand break

References:

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0045027 - DNA end binding

References:

GO:0003678 - DNA helicase activity

References:

GO:0003691 - double-stranded telomeric DNA binding

References:

GO:0051880 - G-quadruplex DNA binding

References:

GO:0043047 - single-stranded telomeric DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Multi-locus phenotype

FYPO:0006087 - abolished DNA resection during replication fork processing

References:

Genotypes:

FYPO:0002472 - abolished histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002597 - abolished histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0002702 - circularized chromosome

References:

Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

References:

Genotypes:

FYPO:0003411 - decreased chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0004867 - decreased histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0005433 - decreased meiotic recombination at hotspot

References:

Genotypes:

FYPO:0005388 - decreased number of Rad51 foci during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0007532 - decreased replication fork colocalization with nuclear pore complex

References:

Genotypes:

FYPO:0003589 - decreased replication slippage during replication fork processing

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0005434 - globally decreased meiotic recombination

References:

Genotypes:

FYPO:0005406 - increased DNA recombination at telomere following meiotic cell cycle

References:

Genotypes:

FYPO:0002596 - increased histone H2A phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0004656 - increased protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0005402 - increased telomeric 3' overhang length during vegetative growth

References:

Genotypes:

FYPO:0000316 - inviable after spore germination

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006323 - loss of viability following replication fork stalling

References:

Genotypes:

FYPO:0006319 - normal extent of DNA resection during replication fork processing

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0007149 - normal growth on N-methyl-N'-nitro-N-nitrosoguanidine

References:

Genotypes:

FYPO:0005936 - normal intragenic meiotic recombination frequency

References:

Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0006320 - normal replication slippage during replication fork processing

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0005549 - normal viability upon nitrogen starvation

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0003858 - sensitive to etoposide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0005919 - sensitive to TOP-53

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0005403 - telomeric 3' overhang absent during vegetative growth

References:

Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

Protein features

PBO:0111792 - AAA family ATPase

PBO:0111821 - SMC family

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001352 - abnormal chromatin organization during vegetative growth

References:

Genotypes:

FYPO:0005913 - abnormal chromatin remodeling during meiosis I

References:

Genotypes:

FYPO:0000427 - abnormal G1 to G0 transition

References:

Genotypes:

FYPO:0003564 - abnormal meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

References:

Genotypes:

FYPO:0005268 - abnormal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0003088 - abnormal replication fork arrest

References:

Genotypes:

FYPO:0002254 - abnormal telomere morphology during vegetative growth

References:

Genotypes:

FYPO:0005453 - abolished break-induced loss of heterozygosity via chromosomal translocation

References:

Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0000484 - abolished meiotic recombination

References:

Genotypes:

FYPO:0005140 - abolished meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0003486 - abolished protein localization to double-strand break site

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0005451 - decreased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0006677 - decreased DNA binding at double-strand break

References:

Genotypes:

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0004867 - decreased histone H2A phosphorylation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

Genotypes:

FYPO:0005433 - decreased meiotic recombination at hotspot

References:

Genotypes:

FYPO:0005141 - decreased meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0005431 - decreased mitotic recombination at hotspot

References:

Genotypes:

FYPO:0005388 - decreased number of Rad51 foci during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0003589 - decreased replication slippage during replication fork processing

References:

Genotypes:

FYPO:0005375 - decreased sister chromatid meiotic recombination

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0005911 - delayed onset of meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0005914 - elongated linear element

References:

Genotypes:

FYPO:0009077 - increased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009052 - increased cell population growth on glutamate nitrogen source

References:

Genotypes:

FYPO:0009101 - increased cell population growth on glycerol and galactose carbon source

References:

Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009093 - increased cell population growth on lysine and serine nitrogen source

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0009028 - increased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0009074 - increased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0009096 - increased cell population growth on xylose carbon source

References:

Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0000657 - increased DNA binding

References:

Genotypes:

FYPO:0004260 - increased duration of protein localization to double-strand break site

References:

Genotypes:

FYPO:0001386 - increased haploidization

References:

Genotypes:

FYPO:0002484 - increased intergenic meiotic recombination

References:

Genotypes:

FYPO:0004057 - increased intragenic meiotic recombination

References:

Genotypes:

FYPO:0000487 - increased meiotic recombination

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0006322 - increased protein localization to chromatin at stalled replication fork

References:

Genotypes:

FYPO:0002475 - increased protein localization to double-strand break site

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0004665 - linear elements absent from cell

References:

Genotypes:

FYPO:0006323 - loss of viability following replication fork stalling

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0001929 - normal cell cycle regulation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001927 - normal cell cycle regulation during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0004286 - normal double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0003082 - normal genetic imprinting at mating-type locus

References:

Genotypes:

FYPO:0004229 - normal growth during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0005942 - normal intergenic meiotic recombination frequency

References:

Genotypes:

FYPO:0005936 - normal intragenic meiotic recombination frequency

References:

Genotypes:

FYPO:0005912 - normal meiosis-specific chromatin remodeling

References:

Genotypes:

FYPO:0005136 - normal meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0000488 - normal meiotic recombination

References:

Genotypes:

FYPO:0004059 - normal meiotic recombination at CRE promoter

References:

Genotypes:

FYPO:0005138 - normal meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0005373 - normal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0002554 - normal protein localization to double-strand break site

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0009032 - resistance to bortezomib

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

References:

Genotypes:

FYPO:0002634 - resistance to cobalt

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

References:

Genotypes:

FYPO:0009039 - resistance to potassium chloride

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0005266 - resistance to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009040 - resistance to tea tree oil

References:

Genotypes:

FYPO:0002767 - resistance to terbinafine

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001188 - sensitive to Calcofluor White

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0003858 - sensitive to etoposide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009084 - sensitive to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001813 - sensitive to N-methyl-N'-nitro-N-nitrosoguanidine

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

References:

Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0005919 - sensitive to TOP-53

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0009064 - sensitive to X-rays and rapamycin during vegetative growth.

References:

Genotypes:

FYPO:0009063 - sensitive to X-rays during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0005455 - telomere assembly at double-strand break site

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF13476AAA_23Rad50/SbcC_AAAPfam
PS51131ZN_HOOKZn_hook_RAD50PROSITE profiles
G3DSA:3.40.50.300:FF:000593CATH-FunFam
G3DSA:3.40.50.300:FF:001195CATH-FunFam
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR18867PANTHER
TIGR00606rad50Rad50_eukaryotesNCBIFAM
CoilCOILS

Orthologs

References / Literature

PMID:23335786 - Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.
Almeida H et al. Nucleic Acids Res 2013 Mar 01;41(5):3056-67
PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52
PMID:15359282 - Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.
Xhemalce B et al. EMBO J 2004 Oct 01;23(19):3844-53
PMID:12019258 - A 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe.
Farah JA et al. Genetics 2002 May;161(1):461-8
PMID:12930957 - Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.
Meister P et al. Nucleic Acids Res 2003 Sep 01;31(17):5064-73
PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.
Gómez EB et al. Genetics 2008 Jun;179(2):757-71
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:12930956 - Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer.
Kibe T et al. Nucleic Acids Res 2003 Sep 01;31(17):5054-63
PMID:17724078 - Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.
Cullen JK et al. Mol Cell Biol 2007 Nov;27(21):7745-57
PMID:18388861 - Mus81 is essential for sister chromatid recombination at broken replication forks.
Roseaulin L et al. EMBO J 2008 May 07;27(9):1378-87
PMID:19470480 - Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination.
Farah JA et al. Proc Natl Acad Sci U S A 2009 Jun 09;106(23):9356-61
PMID:26438724 - H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein.
Stunnenberg R et al. EMBO J 2015 Nov 12;34(22):2789-803
PMID:20065069 - The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.
Willis N et al. Genetics 2010 Apr;184(4):887-97
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:29215009 - The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.
Teixeira-Silva A et al. Nat Commun 2017 Dec 07;8(1):1982
PMID:33836577 - A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
Zdravković A et al. Proc Natl Acad Sci U S A 2021 Mar 16;118(11)
PMID:36361590 - Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe .
Selicky T et al. Int J Mol Sci 2022 Oct 24;23(21)
PMID:17209013 - Role of SUMO in the dynamics of telomere maintenance in fission yeast.
Xhemalce B et al. Proc Natl Acad Sci U S A 2007 Jan 16;104(3):893-8
PMID:19150433 - Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
Hartsuiker E et al. Mol Cell 2009 Jan 16;33(1):117-23
PMID:19023408 - Indistinguishable landscapes of meiotic DNA breaks in rad50+ and rad50S strains of fission yeast revealed by a novel rad50+ recombination intermediate.
Hyppa RW et al. PLoS Genet 2008 Nov;4(11):e1000267
PMID:19139281 - Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions.
Hartsuiker E et al. Mol Cell Biol 2009 Apr;29(7):1671-81
PMID:23093942 - Recovery of arrested replication forks by homologous recombination is error-prone.
Iraqui I et al. PLoS Genet 2012;8(10):e1002976
PMID:12023299 - Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III.
Caspari T et al. Genes Dev 2002 May 15;16(10):1195-208
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:24493214 - ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Deshpande RA et al. EMBO J 2014 Mar 03;33(5):482-500
PMID:28292918 - Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe .
Li Y et al. Genetics 2017 May;206(1):481-496
PMID:29851556 - Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.
Limbo O et al. Mol Biol Cell 2018 Jun 01;29(11):1389-1399
PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.
Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6
PMID:21385875 - Roles of fission yeast Grc3 protein in ribosomal RNA processing and heterochromatic gene silencing.
Kitano E et al. J Biol Chem 2011 Apr 29;286(17):15391-402
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:19211838 - The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling.
Porter-Goff ME et al. Mol Biol Cell 2009 Apr;20(7):2096-107
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:19752195 - Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.
Milman N et al. Mol Cell Biol 2009 Nov;29(22):5998-6005
PMID:28475874 - Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.
Ait Saada A et al. Mol Cell 2017 May 04;66(3):398-410.e4
PMID:11226171 - Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.
Manolis KG et al. EMBO J 2001 Jan 15;20(1-2):210-21
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:19911044 - Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast.
Rothenberg M et al. PLoS Genet 2009 Nov;5(11):e1000722
PMID:21441914 - ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
Williams GJ et al. Nat Struct Mol Biol 2011 Apr;18(4):423-31
PMID:22658721 - Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Latypov VF et al. Mol Cell 2012 Jul 13;47(1):50-60
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:17429064 - Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.
Kibe T et al. Mol Biol Cell 2007 Jun;18(6):2378-87
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