protein coding gene - rga10 (SPAC1565.02c) - RhoGAP, with CRAL-TRIO domain Rga10

Gene summary

Standard name

rga10

Systematic ID

SPAC1565.02c

Product

RhoGAP, with CRAL-TRIO domain Rga10

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

p50RhoGAP, BCH

UniProt ID

Q9P3B1

ORFeome ID

18/18H05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1292405..1293864 reverse strand

Annotation

Protein features

Orthologs

• ARHGAP1 (HGNC:673) Homo sapiens
• rga10 (SJAG_03338) Schizosaccharomyces japonicus
• ECM25 (YJL201W) Saccharomyces cerevisiae

References / Literature

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model

GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.

Decottignies A et al. Genome Res 2003 Mar;13(3):399-406

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:38740643 - Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP.

Shankar S et al. Cell Mol Life Sci 2024 May 13;81(1):216

PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.

Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

GO_REF:0000002 - Comments

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:34006635 - Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation.

Chichili VPR et al. Proc Natl Acad Sci U S A 2021 May 25;118(21)

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17