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protein coding gene - rga10 (SPAC1565.02c) - RhoGAP, with CRAL-TRIO domain Rga10

Gene summary

Standard name
rga10
Systematic ID
SPAC1565.02c
Product
RhoGAP, with CRAL-TRIO domain Rga10
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
p50RhoGAP, BCH
UniProt ID
Q9P3B1
ORFeome ID
18/18H05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1292405..1293864 reverse strand

Annotation

GO biological process

GO:0120010 - intermembrane phospholipid transfer

References:

GO:0007165 - signal transduction

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GO cellular component

GO:0005938 - cell cortex

References:

GO:0032153 - cell division site

References:

GO:0051286 - cell tip

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GO:0005794 - Golgi apparatus

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GO molecular function

GO:0005096 - GTPase activator activity

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GO:0120014 - phospholipid transfer activity

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001118 - abnormal vegetative cell morphology

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Genotypes:

FYPO:0001122 - elongated vegetative cell

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Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000073 - resistance to caffeine

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0001491 - viable vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF13716CRAL_TRIO_2CRAL-TRIO_domPFAM
PF00620RhoGAPRhoGAP_domPFAM
cd00159RhoGAPCDD
cd00170SEC14CRAL-TRIO_domCDD
PS50238RHOGAPRhoGAP_domPROSITE_PROFILES
SM00324RhoGAP_3RhoGAP_domSMART
SSF52087CRAL/TRIO domainCRAL-TRIO_dom_sfSUPERFAMILY
SSF48350GTPase activation domain, GAPRho_GTPase_activation_protSUPERFAMILY
G3DSA:3.40.525.10CRAL-TRIO_dom_sfGENE3D
G3DSA:1.10.555.10Rho GTPase activation proteinRho_GTPase_activation_protGENE3D
PTHR45808RHO GTPASE-ACTIVATING PROTEIN 68FPANTHER

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000002 - Comments
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:34006635 - Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation.
Chichili VPR et al. Proc Natl Acad Sci U S A 2021 May 25;118(21)
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:38740643 - Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP.
Shankar S et al. Cell Mol Life Sci 2024 May 13;81(1):216
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.
Decottignies A et al. Genome Res 2003 Mar;13(3):399-406
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623