protein coding gene - ste4 (SPAC1565.04c) - MAPK cascade adaptor protein Ste4

Gene summary

Standard name

ste4

Systematic ID

SPAC1565.04c

Product

MAPK cascade adaptor protein Ste4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P36622

ORFeome ID

13/13D07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1295316..1296543 reverse strand

Annotation

Protein features

Orthologs

• ste4 (SJAG_03340) Schizosaccharomyces japonicus
• STE50 (YCL032W) Saccharomyces cerevisiae

References / Literature

PMID:15364564 - SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers.

Ramachander R et al. J Mol Biol 2004 Oct 01;342(5):1353-8

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.

Aono T et al. Yeast 1994 Jun;10(6):757-70

PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.

Sieber B et al. Nat Commun 2026 Mar 17;

PMID:9315645 - Multiple regulatory domains on the Byr2 protein kinase.

Tu H et al. Mol Cell Biol 1997 Oct;17(10):5876-87

PMID:1934121 - Pheromone production and response in sterile mutants of fission yeast.

Leupold U et al. Curr Genet 1991 Jul;20(1-2):79-85

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:41974504 - Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.

Bednor L et al. RNA 2026 Apr 13;

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:12171939 - Oligomerization-dependent association of the SAM domains from Schizosaccharomyces pombe Byr2 and Ste4.

Ramachander R et al. J Biol Chem 2002 Oct 18;277(42):39585-93

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:3185514 - The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.

Sipiczki M Mol Gen Genet 1988 Aug;213(2-3):529-34

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:8816472 - Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.

Barr MM et al. Mol Cell Biol 1996 Oct;16(10):5597-603

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:1766866 - The ste4+ gene, essential for sexual differentiation of Schizosaccharomyces pombe, encodes a protein with a leucine zipper motif.

Okazaki N et al. Nucleic Acids Res 1991 Dec;19(25):7043-7

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6