protein coding gene - ste4 (SPAC1565.04c) - MAPK cascade adaptor protein Ste4

Gene summary

Standard name

ste4

Systematic ID

SPAC1565.04c

Product

MAPK cascade adaptor protein Ste4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P36622

ORFeome ID

13/13D07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1295316..1296543 reverse strand

Annotation

Protein features

Orthologs

• ste4 (SJAG_03340) Schizosaccharomyces japonicus
• STE50 (YCL032W) Saccharomyces cerevisiae

References / Literature

PMID:15364564 - SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers.

Ramachander R et al. J Mol Biol 2004 Oct 01;342(5):1353-8

PMID:1934121 - Pheromone production and response in sterile mutants of fission yeast.

Leupold U et al. Curr Genet 1991 Jul;20(1-2):79-85

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:12171939 - Oligomerization-dependent association of the SAM domains from Schizosaccharomyces pombe Byr2 and Ste4.

Ramachander R et al. J Biol Chem 2002 Oct 18;277(42):39585-93

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:9315645 - Multiple regulatory domains on the Byr2 protein kinase.

Tu H et al. Mol Cell Biol 1997 Oct;17(10):5876-87

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:17032641 - Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast.

Mata J et al. Proc Natl Acad Sci U S A 2006 Oct 17;103(42):15517-22

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.

Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:8816472 - Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.

Barr MM et al. Mol Cell Biol 1996 Oct;16(10):5597-603

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:3185514 - The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.

Sipiczki M Mol Gen Genet 1988 Aug;213(2-3):529-34

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:1766866 - The ste4+ gene, essential for sexual differentiation of Schizosaccharomyces pombe, encodes a protein with a leucine zipper motif.

Okazaki N et al. Nucleic Acids Res 1991 Dec;19(25):7043-7

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.

Aono T et al. Yeast 1994 Jun;10(6):757-70