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protein coding gene - atm1 (SPAC15A10.01) - mitochondrial iron-sulfur cluster exporter Atm1

Gene summary

Standard name
atm1
Systematic ID
SPAC15A10.01
Product
mitochondrial iron-sulfur cluster exporter Atm1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC8C9.18
UniProt ID
O14286
ORFeome ID
27/27G04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3675079..3677834 forward strand

Annotation

Complementation

PBO:0024838 - functionally complemented by S. cerevisiae ATM1

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Disease association

MONDO:0010524 - X-linked sideroblastic anemia with ataxia

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GO biological process

GO:0006879 - intracellular iron ion homeostasis

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GO:0016226 - iron-sulfur cluster assembly

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GO:0140466 - iron-sulfur cluster export from the mitochondrion

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GO cellular component

GO:0005743 - mitochondrial inner membrane

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GO:0005739 - mitochondrion

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GO molecular function

GO:0140481 - ABC-type iron-sulfur cluster transporter activity

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GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

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Protein features

PBO:0111874 - ABC transporter family

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000034 - abnormal endocytosis during vegetative growth

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0002653 - decreased vacuolar import

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Genotypes:

FYPO:0002187 - inviable normal volume spheroid vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0004001 - normal cellular glutathione level

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Genotypes:

FYPO:0003849 - normal growth on fluconazole

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Genotypes:

FYPO:0003852 - normal growth on FR901464

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Genotypes:

FYPO:0000979 - normal growth on miconazole

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Genotypes:

FYPO:0003851 - normal growth on MTT

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Genotypes:

FYPO:0003850 - normal growth on oligomycin

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Genotypes:

FYPO:0003719 - normal growth on tributyltin

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Genotypes:

FYPO:0002620 - normal growth on trichostatin A

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0000103 - sensitive to copper

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000843 - sensitive to dithiothreitol

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Genotypes:

FYPO:0000633 - sensitive to G418

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000106 - sensitive to hygromycin B

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0004913 - sensitive to nalidixic acid

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Genotypes:

FYPO:0000271 - sensitive to salt stress

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Genotypes:

FYPO:0002792 - small vacuoles present in increased numbers during cellular hypotonic response

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00005ABC_tranABC_transporter-like_ATP-bdPfam
PF00664ABC_membraneABC1_TM_domPfam
cd03253ABCC_ATM1_transporterCDD
cd18582ABC_6TM_ATM1_ABCB7CDD
PS00211ABC_TRANSPORTER_1ABC_transporter-like_CSPROSITE patterns
PS50893ABC_TRANSPORTER_2ABC_transporter-like_ATP-bdPROSITE profiles
PS50929ABC_TM1FABC1_TM_domPROSITE profiles
SM00382AAAAAA+_ATPaseSMART
G3DSA:1.20.1560.10:FF:000004CATH-FunFam
G3DSA:3.40.50.300:FF:000186CATH-FunFam
G3DSA:1.20.1560.10ABC1_TM_sfCATH-Gene3D
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
SSF90123ABC1_TM_sfSUPERFAMILY
PTHR24221Type_1_exporterPANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:26099175 - The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins.
Lill R et al. Eur J Cell Biol 2015;94(7-9):280-91
PMID:31040179 - Mitochondria export iron-sulfur and sulfur intermediates to the cytoplasm for iron-sulfur cluster assembly and tRNA thiolation in yeast.
Pandey AK et al. J Biol Chem 2019 Jun 14;294(24):9489-9502
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000002 - Comments
PMID:16306692 - Mitochondrial ABC transporter Atm1p is required for protection against oxidative stress and vacuolar functions in Schizosaccharomyces pombe.
Iwaki T et al. Biosci Biotechnol Biochem 2005 Nov;69(11):2109-16
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:21297349 - Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
Akiyama K et al. J Toxicol Sci 2011 Jan;36(1):117-20
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:16849797 - A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant.
Iwaki T et al. Microbiology (Reading) 2006 Aug;152(Pt 8):2309-2321
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838