protein coding gene - ain1 (SPAC15A10.08) - alpha-actinin

Gene summary

Standard name

ain1

Systematic ID

SPAC15A10.08

Product

alpha-actinin

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O13728

ORFeome ID

46/46D09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3692790..3695013 forward strand

Annotation

Protein features

Orthologs

• ACTN1 (HGNC:163) Homo sapiens
• ACTN2 (HGNC:164) Homo sapiens
• ACTN4 (HGNC:166) Homo sapiens
• ain1 (SJAG_04621) Schizosaccharomyces japonicus

References / Literature

PMID:22740629 - α-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly.

Laporte D et al. Mol Biol Cell 2012 Aug;23(16):3094-110

PMID:27075176 - The F-actin bundler α-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast.

Li Y et al. Mol Biol Cell 2016 Jun 01;27(11):1821-33

PMID:33131769 - Cell cycle-dependent phosphorylation of IQGAP is involved in assembly and stability of the contractile ring in fission yeast.

Morita R et al. Biochem Biophys Res Commun 2021 Jan 01;534:1026-1032

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21642440 - Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.

Skau CT et al. J Biol Chem 2011 Jul 29;286(30):26964-77

PMID:14602073 - Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.

Wu JQ et al. Dev Cell 2003 Nov;5(5):723-34

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.

Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:22024167 - Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring.

Chen Q et al. J Cell Biol 2011 Oct 31;195(3):485-98

PMID:31180322 - Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast.

Christensen JR et al. Elife 2019 Jun 10;8

PMID:29343550 - Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.

Willet AH et al. Mol Biol Cell 2018 Mar 15;29(6):713-721

PMID:39330407 - The Myosin-V Myo51 and Alpha-Actinin Ain1p Cooperate during Contractile Ring Assembly and Disassembly in Fission Yeast Cytokinesis.

Tyree ZL et al. J Fungi (Basel) 2024 Sep 12;10(9)

PMID:11294907 - Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis.

Wu JQ et al. Mol Biol Cell 2001 Apr;12(4):1061-77

PMID:26877082 - ER-PM Contacts Define Actomyosin Kinetics for Proper Contractile Ring Assembly.

Zhang D et al. Curr Biol 2016 Mar 07;26(5):647-53

PMID:27069798 - Characterisation of Schizosaccharomyces pombe α-actinin.

Addario B et al. PeerJ 2016;4:e1858

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23770677 - In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics.

Mishra M et al. Nat Cell Biol 2013 Jul;15(7):853-9

PMID:15743909 - Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.

Kovar DR et al. Mol Biol Cell 2005 May;16(5):2313-24

PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99

PMID:32892625 - Molecular Mechanism for the Actin-Binding Domain of α-Actinin Ain1 Elucidated by Molecular Dynamics Simulations and Mutagenesis Experiments.

Morita R et al. J Phys Chem B 2020 Oct 01;124(39):8495-8503

PMID:16866873 - Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast.

Nakano K et al. Genes Cells 2006 Aug;11(8):893-905

PMID:24798735 - The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis.

Wang N et al. J Cell Biol 2014 May 12;205(3):357-75

PMID:25688133 - The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.

Willet AH et al. J Cell Biol 2015 Feb 16;208(4):391-9

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:31509478 - The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 performs a unique essential function in maintenance of cytokinetic ring integrity.

Mangione MC et al. Mol Biol Cell 2019 Oct 15;30(22):2790-2801

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:28338873 - Molecular dissection of the actin-binding ability of the fission yeast α-actinin, Ain1, in vitro and in vivo.

Morita R et al. J Biochem 2017 Aug 01;162(2):93-102

PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Ma Y et al. PLoS One 2011;6(8):e23422

PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.

Wu JQ et al. Science 2005 Oct 14;310(5746):310-4

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs