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protein coding gene - naa10 (SPAC15E1.08) - NatA N-acetyltransferase complex catalytic subunit Naa10

Gene summary

Standard name
naa10
Systematic ID
SPAC15E1.08
Product
NatA N-acetyltransferase complex catalytic subunit Naa10
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ard1
UniProt ID
Q9UTI3
ORFeome ID
18/18G11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3729753..3731015 forward strand

Annotation

Disease association

MONDO:0010671 - microphthalmia, syndromic 1

References:

MONDO:0010457 - Ogden syndrome

References:

GO biological process

GO:0051604 - protein maturation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0031415 - NatA complex

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:1990189 - protein N-terminal-serine acetyltransferase activity

References:

GO:0008999 - protein-N-terminal-alanine acetyltransferase activity

References:

GO:1990190 - protein-N-terminal-glutamate acetyltransferase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002666 - abolished peptide-serine-N-acetyltransferase activity

References:

Genotypes:

FYPO:0002667 - decreased peptide-serine-N-acetyltransferase activity

References:

Genotypes:

FYPO:0002670 - increased peptide-glutamate-N-acetyltransferase activity

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00583Acetyltransf_1GNAT_domPfam
cd04301NAT_SFCDD
PS51186GNATGNAT_domPROSITE profiles
G3DSA:3.40.630.30:FF:000098CATH-FunFam
G3DSA:3.40.630.30CATH-Gene3D
SSF55729Acyl_CoA_acyltransferaseSUPERFAMILY
PTHR23091Ard1-likePANTHER

Orthologs

References / Literature

PMID:23754748 - Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.
Banerjee S et al. Mol Cell Biol 2013 Aug;33(16):3125-36
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:23912279 - Molecular basis for N-terminal acetylation by the heterodimeric NatA complex.
Liszczak G et al. Nat Struct Mol Biol 2013 Sep;20(9):1098-105
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31