protein coding gene - grx2 (SPAC15E1.09) - glutaredoxin Grx2

Gene summary

Standard name

grx2

Systematic ID

SPAC15E1.09

Product

glutaredoxin Grx2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9UTI2

ORFeome ID

08/08D09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3731149..3732340 forward strand

Annotation

Protein features

Orthologs

• GLRX2 (HGNC:16065) Homo sapiens
• GLRX (HGNC:4330) Homo sapiens
• grx2 (SJAG_04632) Schizosaccharomyces japonicus
• GRX1 (YCL035C) Saccharomyces cerevisiae
• GRX2 (YDR513W) Saccharomyces cerevisiae

References / Literature

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:28640807 - Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.

Boronat S et al. PLoS Genet 2017 Jun;13(6):e1006858

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:15358115 - Differential expression and role of two dithiol glutaredoxins Grx1 and Grx2 in Schizosaccharomyces pombe.

Chung WH et al. Biochem Biophys Res Commun 2004 Sep 03;321(4):922-9

PMID:12521308 - Pap1-dependent regulation of the GSTII gene from the fission yeast.

Lim CJ et al. Mol Cells 2002 Dec 31;14(3):431-6

PMID:15865206 - Carbon source-dependent regulation of a second gene encoding glutaredoxin from the fission yeast Schizosaccharomyces pombe.

Kim HG et al. Mol Biol Rep 2005 Mar;32(1):15-24

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:20085751 - Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.

Kim KD et al. Biochem Biophys Res Commun 2010 Feb 12;392(3):467-72

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .

Guydosh NR et al. Elife 2017 Sep 25;6

PMID:15796926 - Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe.

Chung WH et al. Biochem Biophys Res Commun 2005 May 06;330(2):604-10

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7