PomBase home

protein coding gene - nxt2 (SPAC15F9.03c) - nuclear import protein Nxt2

Gene summary

Standard name
nxt2
Systematic ID
SPAC15F9.03c
Product
nuclear import protein Nxt2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ntf2, nft2, SPAC1B9.01c
UniProt ID
Q10100
ORFeome ID
51/51B07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2400650..2401595 reverse strand

Annotation

GO biological process

GO:0006606 - protein import into nucleus

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005635 - nuclear envelope

References:

GO:0031965 - nuclear membrane

References:

GO:0044613 - nuclear pore central transport channel

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0061608 - nuclear import signal receptor activity

References:

GO:0031267 - small GTPase binding

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02136NTF2NTF2_domPFAM
cd00780NTF2Nuclear_transport_factor_2_eukCDD
PS50177NTF2_DOMAINNuclear_transport_factor_2_eukPROSITE_PROFILES
G3DSA:3.10.450.50:FF:000005FUNFAM
SSF54427NTF2-likeNTF2-like_dom_sfSUPERFAMILY
G3DSA:3.10.450.50GENE3D
PTHR12612NUCLEAR TRANSPORT FACTOR 2NTF2PANTHER

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:17651922 - Identification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction.
Oki M et al. Gene 2007 Oct 01;400(1-2):114-21
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101