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protein coding gene - crp79 (SPAC1610.03c) - poly(A) binding protein Crp79

Gene summary

Standard name
crp79
Systematic ID
SPAC1610.03c
Product
poly(A) binding protein Crp79
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
meu5
UniProt ID
Q9P6M8
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1792433..1794972 reverse strand

Annotation

GO biological process

GO:0006406 - mRNA export from nucleus

References:

GO:0048255 - mRNA stabilization

References:

GO:1902373 - negative regulation of mRNA catabolic process

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0010494 - cytoplasmic stress granule

References:

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0003730 - mRNA 3'-UTR binding

References:

GO:0008143 - poly(A) binding

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GO:0008266 - poly(U) RNA binding

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GO:0003723 - RNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

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Multi-locus phenotype

FYPO:0002522 - decreased poly(A)+ mRNA export from nucleus

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003027 - normal poly(A)+ mRNA export from nucleus

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Protein features

PBO:0111764 - rrm RNA recognition motif

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000348 - abnormal spore morphology

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009100 - decreased cell population growth on glycerol and galactose carbon source

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

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Genotypes:

FYPO:0003029 - decreased mRNA splicing, via spliceosome

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Genotypes:

FYPO:0007605 - decreased outer prospore membrane breakdown

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Genotypes:

FYPO:0003550 - decreased protein level during meiosis

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0000584 - decreased sporulation frequency

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0004926 - increased ascospore wall thickness

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Genotypes:

FYPO:0003554 - increased degradation of middle meiotic gene mRNA during late meiosis

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Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

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Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

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Genotypes:

FYPO:0000760 - normal mating

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0003027 - normal poly(A)+ mRNA export from nucleus

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000085 - sensitive to camptothecin

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007604 - smooth ascospore wall

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0000110 - orthologs cannot be distinguished

Protein features

IDNameInterPro nameDB name
PF00076RRM_1RRM_domPfam
cd21619RRM1_Crp79CDD
cd21621RRM2_Crp79_Mug28CDD
cd21622RRM3_Crp79_Mug28CDD
PS50102RRMRRM_domPROSITE profiles
SM00360RRMRRM_domSMART
G3DSA:3.30.70.330Nucleotide-bd_a/b_plait_sfCATH-Gene3D
SSF54928RBD_domain_sfSUPERFAMILY
PTHR48025Euk_RNA-bind_protPANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:12181330 - Crp79p, like Mex67p, is an auxiliary mRNA export factor in Schizosaccharomyces pombe.
Thakurta AG et al. Mol Biol Cell 2002 Aug;13(8):2571-84
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:17651922 - Identification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction.
Oki M et al. Gene 2007 Oct 01;400(1-2):114-21
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.
Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.
Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:33202882 - The Fission Yeast RNA-Binding Protein Meu5 Is Involved in Outer Forespore Membrane Breakdown during Spore Formation.
Zhang B et al. J Fungi (Basel) 2020 Nov 13;6(4)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22558440 - Cuf2 is a novel meiosis-specific regulatory factor of meiosis maturation.
Ioannoni R et al. PLoS One 2012;7(4):e36338
PMID:22737087 - The CCR4-NOT complex is implicated in the viability of aneuploid yeasts.
Tange Y et al. PLoS Genet 2012;8(6):e1002776
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:11376151 - Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe.
Watanabe T et al. Nucleic Acids Res 2001 Jun 01;29(11):2327-37
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60