protein coding gene - ptb1 (SPAC167.02) - geranylgeranyltransferase II beta subunit Ptb1

Gene summary

Standard name: ptb1
Systematic ID: SPAC167.02
Product: geranylgeranyltransferase II beta subunit Ptb1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: P46960
ORFeome ID: 18/18F04
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 1554880..1558354 reverse strand

Annotation

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO_REF:0000024

GO:0072659 - protein localization to plasma membrane

References:

GO_REF:0000111

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO:0005968 - Rab-protein geranylgeranyltransferase complex

References:

GO_REF:0000024

GO molecular function

GO:0004663 - Rab geranylgeranyltransferase activity

References:

GO_REF:0000024

GO:0031267 - small GTPase binding

References:

GO_REF:0000024

GO:0008270 - zinc ion binding

References:

GO_REF:0000024

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

ptb1delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

ptb1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

ptb1delta

FYPO:0006518 - loss of viability in G0

References:

PMID:19366728

Genotypes:

ptb1-124(S233P aa)

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00432	Prenyltrans	Prenyltrans	PFAM
cd02894	GGTase-II	Ptb1	CDD
G3DSA:1.50.10.20:FF:000012			FUNFAM
SSF48239	Terpenoid cyclases/Protein prenyltransferases	Terpenoid_cyclase/PrenylTrfase	SUPERFAMILY
G3DSA:1.50.10.20			GENE3D
PTHR11774	GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT	PGGT1B-like	PANTHER

Orthologs

RABGGTB (HGNC:9796) Homo sapiens
ptb1 (SJAG_04434) Schizosaccharomyces japonicus
BET2 (YPR176C) Saccharomyces cerevisiae

References / Literature

PMID:19366728 - Genetic control of cellular quiescence in S. pombe.: Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7