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protein coding gene - pga1 (SPAC167.09) - GPI-mannosyltransferase II complex subunit Pga1

Gene summary

Standard name
pga1
Systematic ID
SPAC167.09
Product
GPI-mannosyltransferase II complex subunit Pga1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
C6Y4B3
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1558506..1559475 forward strand

Annotation

GO biological process

GO:0006506 - GPI anchor biosynthetic process

References:

GO cellular component

GO:0005789 - endoplasmic reticulum membrane

References:

GO:0120097 - glycosylphosphatidylinositol-mannosyltransferase II complex

References:

GO molecular function

GO:0030234 - enzyme regulator activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

Warnings

PBO:0000070 - gene structure updated

References:

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
PF10333Pga1GPI_ManTrfase_II_coact_Pga1Pfam
PTHR28022GPI_ManTrfase_II_coact_Pga1PANTHER
Transmembrane alpha helixDeepTMHMM
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105