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protein coding gene - rpc19 (SPAC1687.01) - DNA-directed RNA polymerase I and III subunit Rpc19

Gene summary

Standard name
rpc19
Systematic ID
SPAC1687.01
Product
DNA-directed RNA polymerase I and III subunit Rpc19
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rpa17, SPAPYUL23.01
UniProt ID
Q09177
ORFeome ID
06/06B07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 903025..903861 forward strand

Annotation

Complementation

PBO:0000650 - functionally complements S. cerevisiae RPC19

References:

Disease association

MONDO:0013385 - Treacher Collins syndrome 2

References:

MONDO:0002457 - Treacher-Collins syndrome

References:

GO biological process

GO:0006360 - transcription by RNA polymerase I

References:

GO:0006383 - transcription by RNA polymerase III

References:

GO:0006362 - transcription elongation by RNA polymerase I

References:

GO cellular component

GO:0005736 - RNA polymerase I complex

References:

GO:0005666 - RNA polymerase III complex

References:

GO molecular function

GO:0003677 - DNA binding

References:

GO:0003899 - DNA-directed RNA polymerase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0005371 - increased linear minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF13656RNA_pol_L_2RBP11-like_dimerPFAM
cd07029RNAP_I_III_AC19RNAP_AC19CDD
PS01154RNA_POL_L_13KDRNA_pol_Rpb11_13-16kDa_CSPROSITE_PATTERNS
G3DSA:3.30.1360.10:FF:000006FUNFAM
SSF55257RBP11-like subunits of RNA polymeraseRBP11-likeSUPERFAMILY
G3DSA:3.30.1360.10RBP11-likeGENE3D
PTHR13946DNA-DIRECTED RNA POLYMERASE I,II,IIIPANTHER
MF_00261RNApol_arch_Rpo11Rpo11-likeHAMAP

Orthologs

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:10079952 - [Molecular cloning and characteristics of rpc19+ and rpc40+ Schizosaccharomyces pombe genes, coding for common subunits of nuclear RNA polymerase I and III].
Shpakovskiĭ GV et al. Bioorg Khim 1998 Dec;24(12):933-7
PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.
Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PB_REF:0000003 - Disease Association Curation
PMID:10102372 - The fission yeast rpa17+ gene encodes a functional homolog of AC19, a subunit of RNA polymerases I and III of Saccharomyces cerevisiae.
Imai K et al. Mol Gen Genet 1999 Mar;261(2):364-73
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33536435 - Conserved strategies of RNA polymerase I hibernation and activation.
Heiss FB et al. Nat Commun 2021 Feb 03;12(1):758
PMID:10628857 - Isolation and characterization of the fission yeast gene rpa42+, which encodes a subunit shared by RNA polymerases I and III.
Imazawa Y et al. Mol Gen Genet 1999 Dec;262(4-5):749-57
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:10541858 - Rpc19 and Rpc40, two alpha-like subunits shared by nuclear RNA polymerases I and III, are interchangeable between the fission and budding yeasts.
Shpakovski GV et al. Curr Genet 1999 Oct;36(4):208-14
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:8972853 - Fission yeast genes which disrupt mitotic chromosome segregation when overexpressed.
Javerzat JP et al. Nucleic Acids Res 1996 Dec 01;24(23):4676-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000002 - Comments
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:25392932 - RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.
Legros P et al. PLoS Genet 2014 Nov;10(11):e1004794
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105