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protein coding gene - mcb1 (SPAC1687.04) - MCM binding protein homolog Mcb1

Gene summary

Standard name
mcb1
Systematic ID
SPAC1687.04
Product
MCM binding protein homolog Mcb1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94450
ORFeome ID
45/45A03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 906797..908799 forward strand

Annotation

GO biological process

GO:0033260 - nuclear DNA replication

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GO cellular component

GO:0000785 - chromatin

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GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005654 - nucleoplasm

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GO:0005634 - nucleus

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GO molecular function

GO:0003682 - chromatin binding

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0000062 - abnormal nuclear morphology during vegetative growth

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Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

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Genotypes:

Qualitative gene expression

PomGeneEx:0000023 - protein level constant

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000448 - abnormal MCM complex assembly

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Genotypes:

FYPO:0000051 - abnormal meiosis

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Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

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Genotypes:

FYPO:0000062 - abnormal nuclear morphology during vegetative growth

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Genotypes:

FYPO:0001508 - abolished protein localization to chromatin during vegetative growth

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Genotypes:

FYPO:0001122 - elongated vegetative cell

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Genotypes:

FYPO:0000455 - increased number of double-strand break sites during vegetative growth

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Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

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Genotypes:

FYPO:0002262 - inviable after spore germination, multiple cell divisions, elongated cell

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Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

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Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF09739MCM_bindMCM_complex-bdPfam
PTHR13489MCM_complex-bdPANTHER

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23322785 - The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication.
Santosa V et al. J Biol Chem 2013 Mar 08;288(10):6864-80
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:22036784 - Purification and functional inactivation of the fission yeast MCM(MCM-BP) complex.
Li JJ et al. FEBS Lett 2011 Dec 15;585(24):3850-5
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21813639 - Schizosaccharomyces pombe minichromosome maintenance-binding protein (MCM-BP) antagonizes MCM helicase.
Ding L et al. J Biol Chem 2011 Sep 23;286(38):32918-30