protein coding gene - csn5 (SPAC1687.13c) - COP9/signalosome complex protease subunit Csn5

Gene summary

Standard name

csn5

Systematic ID

SPAC1687.13c

Product

COP9/signalosome complex protease subunit Csn5

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O94454

ORFeome ID

16/16E01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 926394..927626 reverse strand

Annotation

Protein features

Orthologs

• COPS5 (HGNC:2240) Homo sapiens
• csn5 (SJAG_00720) Schizosaccharomyces japonicus
• RRI1 (YDL216C) Saccharomyces cerevisiae

References / Literature

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:15769255 - Nep1, a Schizosaccharomyces pombe deneddylating enzyme.

Zhou L et al. Biochem J 2005 Jul 15;389(Pt 2):307-14

PMID:23535663 - CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.

Wu S et al. Nat Commun 2013;4:1642

PMID:16252005 - Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.

Liu C et al. EMBO J 2005 Nov 16;24(22):3940-51

PMID:19748355 - F-box-directed CRL complex assembly and regulation by the CSN and CAND1.

Schmidt MW et al. Mol Cell 2009 Sep 11;35(5):586-97

PMID:11504566 - The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p.

Zhou C et al. BMC Biochem 2001;2:7

PMID:15793566 - CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability.

Wee S et al. Nat Cell Biol 2005 Apr;7(4):387-91

PMID:11854407 - Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes.

Mundt KE et al. Mol Biol Cell 2002 Feb;13(2):493-502

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:27098497 - CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.

Zeng M et al. Nat Commun 2016 Apr 21;7:11364

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:22673520 - Constitutively active Cullin-RING-Ligases fail to rescue loss of NEDD8 conjugation in Schizosaccharomyces pombe.

Girdwood D et al. FEBS Lett 2012 May 21;586(10):1522-8

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:12718879 - Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.

Zhou C et al. Mol Cell 2003 Apr;11(4):927-38

PMID:12183637 - Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

Cope GA et al. Science 2002 Oct 18;298(5593):608-11

PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62

PMID:23496905 - Nedd8 processing enzymes in Schizosaccharomyces pombe.

O'Donoghue JE et al. BMC Biochem 2013 Mar 15;14:8

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10